Secondary Immunodeficiencies with Predominant Antibody Deficiency: Multidisciplinary Perspectives of Polish Experts

Overview

Journal Cent Eur J Immunol

Publisher Termedia

Specialty Allergy & Immunology

Date 2021 Jan 13

PMID 33437186

Citations 3

Authors

Karina Jahnz-Rozyk

Ewa Wiesik-Szewczyk

Jacek Rolinski

Maciej Siedlar

WiesLaw JEdrzejczak

Wojciech Sydor

Agnieszka Tomaszewska

Affiliations

Soon will be listed here.

Abstract

At present, secondary immune deficiencies have become a clinical problem, recognized in different specialties. The aim of this paper was to increase awareness and support the need for screening at-risk populations. Secondary immune deficiencies result in variety of conditions, but not all of them require immunoglobulin replacement therapy, as specific antibody response might be preserved. Moreover, the management of secondary immune deficiencies vary between countries and different medical disciplines. This literature review presents the most common causes and clinical presentation of secondary immunodeficiencies with predominant impaired antibody production. We present diagnostic guidelines for patients at-risk, with an emphasis on the role of prophylactic vaccination as a treatment and diagnostic tool. This review considers the specificity and disparities of the Polish healthcare system and ultimately, suggests that management teams should include a clinical immunologist experienced in the treatment of humoral immunodeficiencies.

Citing Articles

Current Approach in the Management of Secondary Immunodeficiency in Patients with Hematological Malignancies: Spanish Expert Consensus Recommendations.

Boque C, Sanchez-Ramon S, Cordoba R, Moreno C, Cabezudo E J Clin Med. 2023; 12(19).

PMID: 37835000 PMC: 10573502. DOI: 10.3390/jcm12196356.

Increased Access to Immunoglobulin Replacement Therapy for Patients with Primary Immunodeficiency in Poland Based on Clinical Usage Data of Immunoglobulin G over a 5-Year Period.

Wiesik-Szewczyk E, Zietkiewicz M, Radziwilska-Muc A, Jahnz-Rozyk K J Clin Med. 2023; 12(6).

PMID: 36983431 PMC: 10059916. DOI: 10.3390/jcm12062431.

Secondary Dysgammaglobulinemia in Children with Hematological Malignancies Treated with Targeted Therapies.

Tragiannidis A, Groll A Paediatr Drugs. 2021; 23(5):445-455.

PMID: 34292515 DOI: 10.1007/s40272-021-00461-3.

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