Induced Pluripotent Stem Cell Technology for Spinal Cord Injury: a Promising Alternative Therapy

Overview

Journal Neural Regen Res

Date 2021 Jan 12

PMID 33433463

Citations 10

Authors

Yu Li

Ping-Ping Shen

Bin Wang

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity. Furthermore, spinal cord injury has a long period of disease progression and leads to complications that exert a lot of mental and economic pressure on patients. There are currently a large number of therapeutic strategies for treating spinal cord injury, which range from pharmacological and surgical methods to cell therapy and rehabilitation training. All of these strategies have positive effects in the course of spinal cord injury treatment. This review mainly discusses the problems regarding stem cell therapy for spinal cord injury, including the characteristics and action modes of all relevant cell types. Induced pluripotent stem cells, which represent a special kind of stem cell population, have gained impetus in cell therapy development because of a range of advantages. Induced pluripotent stem cells can be developed into the precursor cells of each neural cell type at the site of spinal cord injury, and have great potential for application in spinal cord injury therapy.

Citing Articles

Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway.

Yang W, Li Y, Tang Y, Tao Z, Yu M, Sun C Stem Cell Res Ther. 2025; 16(1):100.

PMID: 40022159 PMC: 11871753. DOI: 10.1186/s13287-025-04250-4.

Stem Cell-Derived Extracellular Vesicle-Mediated Therapeutic Signaling in Spinal Cord Injury.

Poongodi R, Hsu Y, Yang T, Huang Y, Yang K, Lin H Int J Mol Sci. 2025; 26(2).

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Advancing Spinal Cord Injury Treatment through Stem Cell Therapy: A Comprehensive Review of Cell Types, Challenges, and Emerging Technologies in Regenerative Medicine.

Zeng C Int J Mol Sci. 2023; 24(18).

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Regenerative Potential of Injured Spinal Cord in the Light of Epigenetic Regulation and Modulation.

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Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes.

Xia Y, Yang R, Wang H, Hou Y, Li Y, Zhu J J Tissue Eng. 2023; 13:20417314221143059.

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