Initiated Chemical Vapor Deposition (iCVD) Functionalized Polylactic Acid-Marine Algae Composite Patch for Bone Tissue Engineering

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Jan 12

PMID 33430187

Citations 4

Authors

Wiebke Reichstein

Levke Sommer

Salih Veziroglu

Selin Sayin

Stefan Schroder

Yogendra Kumar Mishra

Eyup Ilker Saygili

Fatih Karayurek

Yahya Acil

Jorg Wiltfang

Aydin Gulses

Franz Faupel

Oral Cenk Aktas

Affiliations

Soon will be listed here.

Abstract

The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP-PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.

Citing Articles

Advances in Antibacterial Polymer Coatings Synthesized via Chemical Vapor Deposition.

Shu H, Chen P, Yang R Chem Bio Eng. 2025; 1(6):516-534.

PMID: 39974606 PMC: 11835172. DOI: 10.1021/cbe.4c00043.

Single-step synthesis of shaped polymeric particles using initiated chemical vapor deposition in liquid crystals.

Jain A, Pal S, Li S, Abbott N, Yang R Sci Adv. 2024; 10(45):eadp5573.

PMID: 39504375 PMC: 11540036. DOI: 10.1126/sciadv.adp5573.

Prospective applications of bioactive materials in orthopedic therapies: A review.

Liang W, Zhou C, Bai J, Zhang H, Long H, Jiang B Heliyon. 2024; 10(16):e36152.

PMID: 39247306 PMC: 11379564. DOI: 10.1016/j.heliyon.2024.e36152.

Antibacterial properties of marine algae incorporated polylactide acid membranes as an alternative to clinically applied different collagen membranes.

Weitkamp J, El Hajjami S, Acil Y, Spille J, Sayin S, Sukran Okudan E J Mater Sci Mater Med. 2024; 35(1):9.

PMID: 38285196 PMC: 10824850. DOI: 10.1007/s10856-024-06778-y.

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation.

Veziroglu S, Ayna M, Kohlhaas T, Sayin S, Fiutowski J, Mishra Y Polymers (Basel). 2021; 13(6).

PMID: 33801946 PMC: 8001715. DOI: 10.3390/polym13060847.

References

Llopis-Hernandez V, Rico P, Ballester-Beltran J, Moratal D, Salmeron-Sanchez M . Role of surface chemistry in protein remodeling at the cell-material interface. PLoS One. 2011; 6(5):e19610. PMC: 3090403. DOI: 10.1371/journal.pone.0019610. View

Terriza A, Vilches-Perez J, Gonzalez-Caballero J, de la Orden E, Yubero F, Barranco A . Osteoblasts Interaction with PLGA Membranes Functionalized with Titanium Film Nanolayer by PECVD. Assessment of Surface Influence on Cell Adhesion during Initial Cell to Material Interaction. Materials (Basel). 2017; 7(3):1687-1708. PMC: 5453252. DOI: 10.3390/ma7031687. View

Garrison T, Murawski A, Quirino R . Bio-Based Polymers with Potential for Biodegradability. Polymers (Basel). 2019; 8(7). PMC: 6432354. DOI: 10.3390/polym8070262. View

Vatansever E, Arslan D, Nofar M . Polylactide cellulose-based nanocomposites. Int J Biol Macromol. 2019; 137:912-938. DOI: 10.1016/j.ijbiomac.2019.06.205. View

Mead T, Lefebvre V . Proliferation assays (BrdU and EdU) on skeletal tissue sections. Methods Mol Biol. 2014; 1130:233-243. PMC: 4074019. DOI: 10.1007/978-1-62703-989-5_17. View

Choy S, Lam D, Lee S, Hwang D . Prolonged Biodegradation and Improved Mechanical Stability of Collagen via Vapor-Phase Ti Stitching for Long-Term Tissue Regeneration. ACS Appl Mater Interfaces. 2019; 11(42):38440-38447. DOI: 10.1021/acsami.9b12196. View

Kashirina A, Yao Y, Liu Y, Leng J . Biopolymers as bone substitutes: a review. Biomater Sci. 2019; 7(10):3961-3983. DOI: 10.1039/c9bm00664h. View

Filippi M, Born G, Chaaban M, Scherberich A . Natural Polymeric Scaffolds in Bone Regeneration. Front Bioeng Biotechnol. 2020; 8:474. PMC: 7253672. DOI: 10.3389/fbioe.2020.00474. View

Park S, Lee D, Lee H, Moon H, Lee B, Ko W . Generation of functionalized polymer nanolayer on implant surface via initiated chemical vapor deposition (iCVD). J Colloid Interface Sci. 2014; 439:34-41. DOI: 10.1016/j.jcis.2014.10.018. View

10.

Su C, Hu Y, Song Q, Ye Y, Gao L, Li P . Initiated Chemical Vapor Deposition of Graded Polymer Coatings Enabling Antibacterial, Antifouling, and Biocompatible Surfaces. ACS Appl Mater Interfaces. 2020; 12(16):18978-18986. DOI: 10.1021/acsami.9b22611. View

11.

Wu T, Yang M, Hsu Y . Improvement of cytocompatibility of polylactide by filling with marine algae powder. Mater Sci Eng C Mater Biol Appl. 2015; 50:309-16. DOI: 10.1016/j.msec.2015.02.020. View

12.

Xu S, Chen X, Yang X, Zhang L, Yang G, Shao H . Preparation and In Vitro Biological Evaluation of Octacalcium Phosphate/Bioactive Glass-Chitosan/ Alginate Composite Membranes Potential for Bone Guided Regeneration. J Nanosci Nanotechnol. 2016; 16(6):5577-85. DOI: 10.1166/jnn.2016.11734. View

13.

Mansurnezhad R, Ghasemi-Mobarakeh L, Coclite A, Beigi M, Gharibi H, Werzer O . Fabrication, characterization and cytocompatibility assessment of gelatin nanofibers coated with a polymer thin film by initiated chemical vapor deposition. Mater Sci Eng C Mater Biol Appl. 2020; 110:110623. DOI: 10.1016/j.msec.2019.110623. View

14.

Li D, Jiang Y, Lv S, Liu X, Gu J, Chen Q . Preparation of plasticized poly (lactic acid) and its influence on the properties of composite materials. PLoS One. 2018; 13(3):e0193520. PMC: 5832258. DOI: 10.1371/journal.pone.0193520. View

15.

Daris B, Knez Z . Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering. Acta Pharm. 2019; 70(1):1-15. DOI: 10.2478/acph-2020-0007. View

16.

Abd El-Hack M, Abdelnour S, Alagawany M, Abdo M, Sakr M, Khafaga A . Microalgae in modern cancer therapy: Current knowledge. Biomed Pharmacother. 2018; 111:42-50. DOI: 10.1016/j.biopha.2018.12.069. View

17.

Mokhena T, Sefadi J, Sadiku E, John M, Mochane M, Mtibe A . Thermoplastic Processing of PLA/Cellulose Nanomaterials Composites. Polymers (Basel). 2019; 10(12). PMC: 6401737. DOI: 10.3390/polym10121363. View

18.

Ishikawa K, Ueyama Y, Mano T, Koyama T, Suzuki K, Matsumura T . Self-setting barrier membrane for guided tissue regeneration method: initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions. J Biomed Mater Res. 1999; 47(2):111-5. DOI: 10.1002/(sici)1097-4636(199911)47:2<111::aid-jbm1>3.0.co;2-0. View

19.

Chan K, Gleason K . Initiated chemical vapor deposition of linear and cross-linked poly(2-hydroxyethyl methacrylate) for use as thin-film hydrogels. Langmuir. 2005; 21(19):8930-9. DOI: 10.1021/la051004q. View

20.

Wu L, Morrow B, Jefferson M, Li F, Hong L . Antibacterial Collagen Composite Membranes Containing Minocycline. J Pharm Sci. 2020; 110(5):2177-2184. DOI: 10.1016/j.xphs.2020.12.026. View