Hepatoprotective Activity of Silymarin Encapsulation Against Hepatic Damage in Albino Rats

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2021 Jan 11

PMID 33424359

Citations 12

Authors

Shanza Mukhtar

Zeng Xiaoxiong

Samina Qamer

Muhammad Saad

Muhammad Samee Mubarik

Ahmed Hossam Mahmoud

Osama B Mohammed

Affiliations

Soon will be listed here.

Abstract

Liver fibrosis occurs due to liver injuries and toxins. Silymarin (SMR) extracted by the milk thistle seeds, is widely used such as herbal drug for its hepatoprotective properties. The purpose of this study to assess the properties of an optimized dose of encapsulated crude SMR on antidiabetic activity and liver fibrosis induced by paracetamol in male albino rat. Hepatic fibrosis was assessed by measuring liver enzymes. Results revealed that the consumption of encapsulated SMR, can effectively affluence the target and avoid the degradation of bioactive compound. Body weight of animal also significantly increased in each group during all the period. According to our optimized study, the long-term induction of SMR (300 mg/kg) significantly amplified survival time of rats with paracetamol induced hepatic injuries. The changes of liver fibrosis and the significant increase of hepatic enzyme biomarkers were also observed. In conclusion, the results suggest that SMR acts as a hepatoprotective agent by inhibiting the fibrogenisis and apoptosis in liver, as well as insulin resistance.

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