Attitude and Awareness of Public Towards Genetic Testing in Riyadh, Saudi Arabia

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2021 Jan 11

PMID 33424305

Citations 9

Authors

Azher Arafah

Mohammed H Aljawadi

Mohammed Aldheefi

Muneeb U Rehman

Affiliations

Soon will be listed here.

Abstract

The current study was designed to evaluate the attitude of the Saudi general population towards knowledge, perception and awareness about genetic testing. Using a convenience sampling technique, an online survey was used to collect the data. The survey consisted of 16 questions that covered basic demographics and several scenarios that assess subjects' perceptions regarding genetic testing. Answering all questions was required for completing the survey. Among 333 subjects, 53.5% were male, 18.9% were married, and 99.4% were muslims. Around 75% has/will have a bachelor degree. About 59% were students. About 87% would consider genetic testing before marriage and similar percentage would not consider conceiving a child if the genetic screening indicated that there is 100% chance the child will be born with genetic disorder. Neither marital status (Single = 87.04%, married = 87.30% (P = 0.955)) nor gender (male = 85.96, female = 88.39 (P = 0.509)) affected the aforementioned decision. When subjects were asked if they would choose abortion knowing that the embryo has a severe genetic disorder, 62.7% answered yes. In general, 80.4% were willing to be recruited into a genetics study, married subjects were more reluctant to be recruited compared to singles (30% and 17% (P = 0.018) respectively). There was no difference between males and females in the decision of joining a genetic study. Also 78.4% supported creation of genetic disease database and family maps. 69.7% of the participants supported government enforcement of the genetic testing, 56.2% supported government-run facilities for Saudi citizens to have genetic tests. We conclude that married people were in favor of genetic testing than the single counterparts, secondly, single status people supported the idea of having genetic tests before their marriage they were supportive of the idea of the government taking a leading role in enforcing the genetic testing and creation of the genetic banks.

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References

Alhamdan N, Almazrou Y, Alswaidi F, Choudhry A . Premarital screening for thalassemia and sickle cell disease in Saudi Arabia. Genet Med. 2007; 9(6):372-7. DOI: 10.1097/gim.0b013e318065a9e8. View

Oliveri S, Masiero M, Arnaboldi P, Cutica I, Fioretti C, Pravettoni G . Health Orientation, Knowledge, and Attitudes toward Genetic Testing and Personalized Genomic Services: Preliminary Data from an Italian Sample. Biomed Res Int. 2017; 2016:6824581. PMC: 5220460. DOI: 10.1155/2016/6824581. View

Memish Z, Saeedi M . Six-year outcome of the national premarital screening and genetic counseling program for sickle cell disease and β-thalassemia in Saudi Arabia. Ann Saudi Med. 2011; 31(3):229-35. PMC: 3119961. DOI: 10.4103/0256-4947.81527. View

Zhao J, Grant S . Advances in whole genome sequencing technology. Curr Pharm Biotechnol. 2010; 12(2):293-305. DOI: 10.2174/138920111794295729. View

Calsbeek H, Morren M, Bensing J, Rijken M . Knowledge and attitudes towards genetic testing: a two year follow-up study in patients with asthma, diabetes mellitus and cardiovascular disease. J Genet Couns. 2007; 16(4):493-504. PMC: 6338710. DOI: 10.1007/s10897-006-9085-9. View

Alkuraya F . Genetics and genomic medicine in Saudi Arabia. Mol Genet Genomic Med. 2014; 2(5):369-78. PMC: 4190871. DOI: 10.1002/mgg3.97. View

Laskey S, Williams J, Pierre-Louis J, ORiordan M, Matthews A, Robin N . Attitudes of African American premedical students toward genetic testing and screening. Genet Med. 2003; 5(1):49-54. DOI: 10.1097/00125817-200301000-00008. View

Hann K, Freeman M, Fraser L, Waller J, Sanderson S, Rahman B . Awareness, knowledge, perceptions, and attitudes towards genetic testing for cancer risk among ethnic minority groups: a systematic review. BMC Public Health. 2017; 17(1):503. PMC: 5445407. DOI: 10.1186/s12889-017-4375-8. View

Aldahmesh M, Abu-Safieh L, Khan A, Al-Hassnan Z, Shaheen R, Rajab M . Allelic heterogeneity in inbred populations: the Saudi experience with Alström syndrome as an illustrative example. Am J Med Genet A. 2009; 149A(4):662-5. DOI: 10.1002/ajmg.a.32753. View

10.

Alkuraya F . Impact of new genomic tools on the practice of clinical genetics in consanguineous populations: the Saudi experience. Clin Genet. 2013; 84(3):203-8. DOI: 10.1111/cge.12131. View

11.

Xie Y, Xu Y, Wang J, Miao B, Zeng Y, Ding C . Preliminary analysis of numerical chromosome abnormalities in reciprocal and Robertsonian translocation preimplantation genetic diagnosis cases with 24-chromosomal analysis with an aCGH/SNP microarray. J Assist Reprod Genet. 2017; 35(1):177-186. PMC: 5758468. DOI: 10.1007/s10815-017-1045-9. View

12.

Borry P, Cornel M, Howard H . Where are you going, where have you been: a recent history of the direct-to-consumer genetic testing market. J Community Genet. 2011; 1(3):101-106. PMC: 3063844. DOI: 10.1007/s12687-010-0023-z. View

13.

Henneman L, Timmermans D, van der Wal G . Public experiences, knowledge and expectations about medical genetics and the use of genetic information. Community Genet. 2004; 7(1):33-43. DOI: 10.1159/000080302. View

14.

Vermeulen E, Henneman L, van El C, Cornel M . Public attitudes towards preventive genomics and personal interest in genetic testing to prevent disease: a survey study. Eur J Public Health. 2013; 24(5):768-75. DOI: 10.1093/eurpub/ckt143. View

15.

Qari A, Balobaid A, Rawashdeh R, Al-Sayed M . The development of genetic counseling services and training program in Saudi Arabia. J Genet Couns. 2013; 22(6):835-8. DOI: 10.1007/s10897-013-9645-8. View

16.

Michie S, Di Lorenzo E, Lane R, Armstrong K, Sanderson S . Genetic information leaflets: influencing attitudes towards genetic testing. Genet Med. 2004; 6(4):219-25. DOI: 10.1097/01.gim.0000132685.60259.ea. View

17.

Eum H, Lee M, Yoon J, Cho J, Lee E, Choi K . Differences in attitudes toward genetic testing among the public, patients, and health-care professionals in Korea. Eur J Hum Genet. 2018; 26(10):1432-1440. PMC: 6138694. DOI: 10.1038/s41431-018-0191-6. View

18.

Zimmern R, Kroese M . The evaluation of genetic tests. J Public Health (Oxf). 2007; 29(3):246-50. DOI: 10.1093/pubmed/fdm028. View

19.

Deng H, Zheng W, Song Z . Genetics, molecular biology, and phenotypes of x-linked epilepsy. Mol Neurobiol. 2013; 49(3):1166-80. DOI: 10.1007/s12035-013-8589-1. View

20.

Khitamy B . Divergent views on abortion and the period of ensoulment. Sultan Qaboos Univ Med J. 2013; 13(1):26-31. PMC: 3616796. DOI: 10.12816/0003192. View