Neuromyelitis Optica is an HLA Associated Disease Different from Multiple Sclerosis: a Systematic Review with Meta-analysis

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jan 9

PMID 33420337

Citations 10

Authors

Marcos Papais Alvarenga

Luciana Ferreira do Carmo

Claudia Cristina Ferreira Vasconcelos

Marina Papais Alvarenga

Helcio Alvarenga-Filho

Cleonice Alves de Melo Bento

Carmen Lucia Antao Paiva

Laura Leyva-Fernandez

Oscar Fernandez

Regina Maria Papais-Alvarenga

Affiliations

Soon will be listed here.

Abstract

Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB1*03 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB1*03:01 allele in Western populations and with the DPB1*05:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.

Citing Articles

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