Amino Acid Metabolism in Tumour-bearing Mice

Overview

Journal Biochem J

Specialty Biochemistry

Date 1988 Jan 15

PMID 3342022

Citations 26

Authors

S Rivera

J Azcon-Bieto

F J Lopez-Soriano

M Miralpeix

J M Argiles

Affiliations

Soon will be listed here.

Abstract

Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.

Citing Articles

Bidirectional role of neutrophils in tumor development.

Luyang H, Zeng F, Lei Y, He Q, Zhou Y, Xu J Mol Cancer. 2025; 24(1):22.

PMID: 39819428 PMC: 11737241. DOI: 10.1186/s12943-025-02228-7.

Applying metabolic control strategies to engineered T cell cancer therapies.

Fox A, Blazeck J Metab Eng. 2024; 86:250-261.

PMID: 39490640 PMC: 11611646. DOI: 10.1016/j.ymben.2024.10.009.

Targeting fatty acid oxidation enhances response to HER2-targeted therapy.

Nandi I, Ji L, Smith H, Avizonis D, Papavasiliou V, Lavoie C Nat Commun. 2024; 15(1):6587.

PMID: 39097623 PMC: 11297952. DOI: 10.1038/s41467-024-50998-3.

In Vitro MRS of Cells Treated with Trastuzumab at 1.5 Tesla.

Guz W, Podgorski R, Bober Z, Aebisher D, Truszkiewicz A, Olek M Int J Mol Sci. 2024; 25(3).

PMID: 38338997 PMC: 10855746. DOI: 10.3390/ijms25031719.

Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.

Linder S, Bernasocchi T, Martinez-Pastor B, Sullivan K, Galbraith M, Lewis C Nat Metab. 2023; 5(12):2131-2147.

PMID: 37957387 PMC: 11639397. DOI: 10.1038/s42255-023-00919-3.

References

Knox W, MORRIS H . Glutaminase activities and growth rates of rat hepatomas. Cancer Res. 1969; 29(6):1195-9. View

SAUER L, Stayman 3rd J, Dauchy R . Amino acid, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res. 1982; 42(10):4090-7. View

FAWCETT J, Scott J . A rapid and precise method for the determination of urea. J Clin Pathol. 1960; 13:156-9. PMC: 480024. DOI: 10.1136/jcp.13.2.156. View

Lundholm K, Bylund A, Holm J, Schersten T . Skeletal muscle metabolism in patients with malignant tumor. Eur J Cancer (1965). 1976; 12(6):465-73. DOI: 10.1016/0014-2964(76)90036-0. View

MIDER G . Some aspects of nitrogen and energy metabolism in cancerous subjects: a review. Cancer Res. 1951; 11(11):821-9. View

Lundholm K, Edstrom S, Ekman L, Karlberg I, Bylund A, Schersten T . A comparative study of the influence of malignant tumor on host metabolism in mice and man: evaluation of an experimental model. Cancer. 1978; 42(2):453-61. DOI: 10.1002/1097-0142(197808)42:2<453::aid-cncr2820420212>3.0.co;2-t. View

Moreadith R, Lehninger A . The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem. 1984; 259(10):6215-21. View

Arola L, Palou A, Remesar X, Alemany M . Adenylate deaminase activity in the rat. Effect of 24 hours of fasting. Horm Metab Res. 1981; 13(5):264-6. DOI: 10.1055/s-2007-1019240. View

Lippman M, LASTER W, ABBOTT B, Venditti J, Baratta M . Antitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma. Cancer Res. 1975; 35(4):939-45. View

10.

Demetrakopoulos G, LINN B, Amos H . Rapid loss of ATP by tumor cells deprived of glucose: contrast to normal cells. Biochem Biophys Res Commun. 1978; 82(3):787-94. DOI: 10.1016/0006-291x(78)90851-3. View

11.

Curthoys N, LOWRY O . The distribution of glutaminase isoenzymes in the various structures of the nephron in normal, acidotic, and alkalotic rat kidney. J Biol Chem. 1973; 248(1):162-8. View

12.

Arola L, Palou A, Remesar X, Alemany M . Glutamine synthetase activity in the organs of fed and 24-hours fasted rats. Horm Metab Res. 1981; 13(4):199-202. DOI: 10.1055/s-2007-1019220. View

13.

Carrascosa J, Martinez P, Nunez de Castro I . Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor cells. Cancer Res. 1984; 44(9):3831-5. View

14.

Lazo P . Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells. Eur J Biochem. 1981; 117(1):19-25. DOI: 10.1111/j.1432-1033.1981.tb06297.x. View

15.

Clark C, GOODLAD G . Depletion of proteins of phasic and tonic muscles in tumour-bearing rats. Eur J Cancer (1965). 1971; 7(1):3-9. DOI: 10.1016/0014-2964(71)90088-0. View

16.

Huggett A, Nixon D . Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. Lancet. 1957; 273(6991):368-70. DOI: 10.1016/s0140-6736(57)92595-3. View

17.

Henry N, van Lamsweerde A, Vaes G . Collagen degradation by metastatic variants of Lewis lung carcinoma: cooperation between tumor cells and macrophages. Cancer Res. 1983; 43(11):5321-7. View

18.

LANDEL A, HAMMOND W, Meguid M . Aspects of amino acid and protein metabolism in cancer-bearing states. Cancer. 1985; 55(1 Suppl):230-7. DOI: 10.1002/1097-0142(19850101)55:1+<230::aid-cncr2820551305>3.0.co;2-i. View

19.

Levin L, Gevers W . Metabolic alterations in cancer. Part I. Carbohydrate metabolism. S Afr Med J. 1981; 59(15):518-21. View

20.

Schaur R, Semmelrock H, Schreibmayer W, Tillian H, SCHAUENSTEIN E . Tumor host relations. V. Nitrogen metabolism in Yoshida sarcoma-bearing rats. Reduction of growth rate and increase of survival time by administration of physiological doses of branched-chain amino acids. J Cancer Res Clin Oncol. 1980; 97(3):285-93. DOI: 10.1007/BF00405780. View