MicroRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis

Overview

Journal Cancer Genomics Proteomics

Specialties Biochemistry
Genetics
Oncology

Date 2021 Jan 9

PMID 33419892

Citations 9

Authors

Ulrich H Weidle

Fabian Birzele

Adam Nopora

Affiliations

Soon will be listed here.

Abstract

The annual death toll for gastric cancer is in the range of 700,000 worldwide. Even in patients with early-stage gastric cancer recurrence within five years has been observed after surgical resection and following chemotherapy with therapy-resistant features. Therefore, the identification of new targets and treatment modalities for gastric cancer is of paramount importance. In this review we focus on the role of microRNAs with documented efficacy in preclinical xenograft models with respect to growth of human gastric cancer cells. We have identified 31 miRs (-10b, -19a, -19b, -20a, -23a/b, -25, -27a-3p, -92a, -93, -100, -106a, -130a, -135a, -135b-5p, -151-5p, -187, -199-3p, -215, -221-3p, -224, -340a, -382, -421, -425, -487a, -493, -532-3p, -575, -589, -664a-3p) covering 26 different targets which promote growth of gastric cancer cells in vitro and in vivo as xenografts. Five miRs (miRs -10b, 151-5p, -187, 532-3p and -589) additionally have an impact on metastasis. Thirteen of the identified miRs (-19b, -20a/b, -25, -92a, -106a, -135a, -187, -221-3p, -340a, -421, -493, -575 and -589) have clinical impact on worse prognosis in patients.

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References

Di Giorgio A, Tran T, Duca M . Small-molecule approaches toward the targeting of oncogenic miRNAs: roadmap for the discovery of RNA modulators. Future Med Chem. 2016; 8(7):803-16. DOI: 10.4155/fmc-2016-0018. View

Guo P, Yang D, Sun Z, Xu H . PDCD4 functions as a suppressor for pT2a and pT2b stage gastric cancer. Oncol Rep. 2013; 29(3):1007-12. DOI: 10.3892/or.2013.2232. View

Ozpolat B, Sood A, Lopez-Berestein G . Liposomal siRNA nanocarriers for cancer therapy. Adv Drug Deliv Rev. 2014; 66:110-6. PMC: 4527165. DOI: 10.1016/j.addr.2013.12.008. View

Nguyen D, Chang S . Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs. Int J Mol Sci. 2017; 19(1). PMC: 5796015. DOI: 10.3390/ijms19010065. View

Thomas J, Hergenrother P . Targeting RNA with small molecules. Chem Rev. 2008; 108(4):1171-224. DOI: 10.1021/cr0681546. View

Li C, Lu S, Shi Y . MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2. Oncol Rep. 2017; 37(3):1747-1755. DOI: 10.3892/or.2017.5370. View

Tan F, Thiele C, Li Z . Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncol Lett. 2014; 7(5):1333-1340. PMC: 3997700. DOI: 10.3892/ol.2014.1909. View

Zhu C, Wang J, Shi B, Hu P, Ning B, Zhang Q . The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo. Dig Dis Sci. 2014; 60(1):109-17. DOI: 10.1007/s10620-014-3290-4. View

Yan M, Yang X, Wang H, Shao Q . The critical role of histone lysine demethylase KDM2B in cancer. Am J Transl Res. 2018; 10(8):2222-2233. PMC: 6129528. View

10.

Chan A, Chan M, Lee T, Ng E, Leung W, Lau J . Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer. Oncol Rep. 2005; 13(5):937-41. View

11.

Yuan W, Liu B, Wang X, Li T, Xue H, Mo X . CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer. Cancer Lett. 2016; 386:77-86. DOI: 10.1016/j.canlet.2016.11.015. View

12.

Bennin D, Don A, Brake T, McKenzie J, Rosenbaum H, Ortiz L . Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem. 2002; 277(30):27449-67. DOI: 10.1074/jbc.M111693200. View

13.

Janes K . RUNX1 and its understudied role in breast cancer. Cell Cycle. 2011; 10(20):3461-5. PMC: 3266176. DOI: 10.4161/cc.10.20.18029. View

14.

Wu Z, Zheng S, Li Z, Tan J, Yu Q . E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT. Oncogene. 2011; 30(37):3979-84. DOI: 10.1038/onc.2011.129. View

15.

Yin G, Zhou H, Xue Y, Yao B, Zhao W . MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncol Rep. 2016; 36(2):1111-8. DOI: 10.3892/or.2016.4876. View

16.

Yang G, Gong Y, Wang Q, Wang L, Zhang X . miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene. 2016; 36(8):1023-1037. DOI: 10.1038/onc.2016.270. View

17.

Oh S, Ju Y, Kim S, Park H . PNA-based antisense oligonucleotides for micrornas inhibition in the absence of a transfection reagent. Oligonucleotides. 2010; 20(5):225-30. DOI: 10.1089/oli.2010.0238. View

18.

Han W, Ding P, Xu M, Wang L, Rui M, Shi S . Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003; 81(6):609-17. DOI: 10.1016/s0888-7543(03)00095-8. View

19.

Shi J, Zhang Y, Jin N, Li Y, Wu S, Xu L . MicroRNA-221-3p Plays an Oncogenic Role in Gastric Carcinoma by Inhibiting PTEN Expression. Oncol Res. 2016; 25(4):523-536. PMC: 7841127. DOI: 10.3727/096504016X14756282819385. View

20.

Davis M, Brewster M . Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov. 2004; 3(12):1023-35. DOI: 10.1038/nrd1576. View