Ferroptosis-Related Genes in Neurodevelopment and Central Nervous System

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2021 Jan 9

PMID 33419148

Citations 17

Authors

Soo-Whee Kim

Yujin Kim

Sung Eun Kim

Joon-Yong An

Affiliations

Soon will be listed here.

Abstract

Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

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Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis.

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