From Evidence to Clinical Guidelines in Antibiotic Treatment in Acute Otitis Media in Children

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Jan 9

PMID 33419114

Citations 6

Authors

Elena Lia Spoiala

Gabriela Dumitrita Stanciu

Veronica Bild

Daniela Carmen Ababei

Cristina Gavrilovici

Affiliations

Soon will be listed here.

Abstract

Acute otitis media (AOM) in children represents a public health concern, being one of the leading causes of health care visits and antibiotic prescriptions worldwide. The overall aim of this paper is to unravel the major current insights into the antibiotic treatment of AOM in children. Our approach is three-fold: 1. a preclinical evaluation of antibiotics in animal models of AOM stressing on the advantages of different species when testing for different schemes of antibiotics; 2. an overview on the new antimicrobial agents whose efficacy has been demonstrated in refractory cases of AOM in children; and 3. an analysis of the different guidelines stressing on the differences and similarities between the various schemes of antibiotic treatment. The preferred therapeutic agents remain amoxicillin and the amoxicillin-clavulanate combination for AOM caused by , whereas oral cephalosporin is preferred in AOM due to and . As for the second and third line antimicrobial treatments, there is a wide variety of suggested antibiotic classes with variations in duration and posology. The decision to prescribe antimicrobial treatment as a first-line choice is based on the severity of the symptoms in 16 of the guidelines included in this review.

Citing Articles

Characterization of middle ear microbiome in otitis media with effusion in Hungarian children: may potentially hamper the microbial diversity.

Fekete S, Juhasz J, Makra N, Dunai Z, Kristof K, Ostorhazi E Heliyon. 2024; 10(21):e39380.

PMID: 39524746 PMC: 11547888. DOI: 10.1016/j.heliyon.2024.e39380.

Oral and middle ear delivery of otitis media standard of care antibiotics, but not biofilm-targeted antibodies, alter chinchilla nasopharyngeal and fecal microbiomes.

Duff A, Jurcisek J, Kurbatfinski N, Chiang T, Goodman S, Bakaletz L NPJ Biofilms Microbiomes. 2024; 10(1):10.

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Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum?.

Spoiala E, Starcea I, Ioniuc I, Cozma R, Rusu D, Bozomitu L Medicina (Kaunas). 2023; 59(3).

PMID: 36984521 PMC: 10053714. DOI: 10.3390/medicina59030520.

Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era.

Gavrilovici C, Spoiala E, Miron I, Starcea I, Iliescu Halitchi C, Zetu I Microorganisms. 2022; 10(8).

PMID: 36014016 PMC: 9413688. DOI: 10.3390/microorganisms10081598.

Innate Immunity in the Middle Ear Mucosa.

Massa H, Spann K, Cripps A Front Cell Infect Microbiol. 2021; 11:764772.

PMID: 34778109 PMC: 8586084. DOI: 10.3389/fcimb.2021.764772.

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