Application of CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem

Overview

Journal Nutrients

Date 2021 Jan 9

PMID 33419054

Citations 10

Authors

Leonides Fernandez

Irma Castro

Rebeca Arroyo

Claudio Alba

David Beltran

Juan M Rodriguez

Affiliations

Soon will be listed here.

Abstract

In this study, the cervicovaginal environment of women with reproductive failure (repetitive abortion, infertility of unknown origin) was assessed and compared to that of healthy fertile women. Subsequently, the ability of CECT5713 to increase pregnancy rates in women with reproductive failure was evaluated. Vaginal pH and Nugent score were higher in women with reproductive failure than in fertile women. The opposite was observed regarding the immune factors TGF-β 1, TFG-β 2, and VEFG. Lactobacilli were detected at a higher frequency and concentration in fertile women than in women with repetitive abortion or infertility. The metataxonomic study revealed that vaginal samples from fertile women were characterized by the high abundance of sequences, while DNA from this genus was practically absent in one third of samples from women with reproductive failure. Daily oral administration of CECT5713 (~9 log CFU/day) to women with reproductive failure for a maximum of 6 months resulted in an overall successful pregnancy rate of 56%. The probiotic intervention modified key microbiological, biochemical, and immunological parameters in women who got pregnant. In conclusion, CECT5713 has proved to be a good candidate to improve reproductive success in women with reproductive failure.

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