New Insights of Extrachromosomal DNA in Tumorigenesis and Therapeutic Resistance of Cancer

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2021 Jan 8

PMID 33414985

Citations 6

Authors

Hui Qiu

Zhi-Ying Shao

Xin Wen

Long-Zhen Zhang

Affiliations

Soon will be listed here.

Abstract

In the past few decades, the studies of extrachromosomal DNA (ecDNA), which existed independently of chromosomes, were tepid. However, recent studies on ecDNA rekindled the enthusiasm of oncologists for further studying ecDNA. In this review, we summarized the recent advances of ecDNA in oncogenesis and oncotherapy. ecDNA consists of highly open chromatin, and its circular structure enables ultra-long-range chromatin contacts. ecDNA is not inherited in accordance with Mendel's laws. Furthermore, ecDNA is widely existed in cancer cells, but almost never found in normal cells. It has been found that ecDNA played important roles in tumorigenesis and tumor progression, including oncogene amplification, tumor heterogeneity, enhancer hijacking and genomic rearrangement. More importantly, ecDNA is closely related to cancer treatment resistance. In hence, further understanding of ecDNA would contribute to developing innovative targeting ecDNA therapies.

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