COVID-19: Advances in Diagnostic Tools, Treatment Strategies, and Vaccine Development

Overview

Journal J Biosci

Specialties Biochemistry
Biology

Date 2021 Jan 7

PMID 33410425

Citations 46

Authors

M Sreepadmanabh

Amit Kumar Sahu

Ajit Chande

Affiliations

Soon will be listed here.

Abstract

An unprecedented worldwide spread of the SARS-CoV-2 has imposed severe challenges on healthcare facilities and medical infrastructure. The global research community faces urgent calls for the development of rapid diagnostic tools, effective treatment protocols, and most importantly, vaccines against the pathogen. Pooling together expertise across broad domains to innovate effective solutions is the need of the hour. With these requirements in mind, in this review, we provide detailed critical accounts on the leading efforts at developing diagnostics tools, therapeutic agents, and vaccine candidates. Importantly, we furnish the reader with a multidisciplinary perspective on how conventional methods like serology and RT-PCR, as well as cutting-edge technologies like CRISPR/Cas and artificial intelligence/machine learning, are being employed to inform and guide such investigations. We expect this narrative to serve a broad audience of both active and aspiring researchers in the field of biomedical sciences and engineering and help inspire radical new approaches towards effective detection, treatment, and prevention of this global pandemic.

Citing Articles

SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development.

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PMID: 39852796 PMC: 11769326. DOI: 10.3390/vaccines13010017.

Conventional and Nonconventional Therapies for COVID-19 Management in Trinidad.

Ismaila M, Lall K, Sookram K, Sundaram V, Jones K Scientifica (Cairo). 2024; 2024:1545153.

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Future challenges of direct-to-consumer genetic testing for sustainable safety in the Republic of Korea's skin care market: a systematic review.

Lee J, Kwon K Mhealth. 2024; 10:33.

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Dual Detection of Hepatitis B and C Viruses Using CRISPR-Cas Systems and Lateral Flow Assay.

Shahni S, Albogami S, Azmi I, Pattnaik B, Chaudhuri R, Dev K J Nucleic Acids. 2024; 2024:8819834.

PMID: 39399398 PMC: 11470818. DOI: 10.1155/2024/8819834.

Establishment of a Reference Material in Quality Control for Use in Infectivity and Identity Assays of Recombinant COVID-19 Vaccine, in Accordance with International Standards Organization Guidance.

Ajorio A, Chagas M, Rhodes V, Rodrigues A, Goncalves N, Godinho R Vaccines (Basel). 2024; 12(9).

PMID: 39339999 PMC: 11435733. DOI: 10.3390/vaccines12090967.

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