An Unfortunate Case of Reactivation of Tuberculosis in a Postpartum Female

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2021 Jan 7

PMID 33409022

Citations 3

Authors

Azka Tasleem

Aqsa Mahmood

Anchit Bharat

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) is a widely prevalent disease, especially in resource-limited settings. It poses a big burden to the community and is a significant cause of morbidity and mortality in pregnant females due to their immunosuppressed state. During pregnancy, the immune system is suppressed to prevent fetal rejection, and it gets reconstituted postpartum. During this reconstitution phase, reactivation of TB may occur, making it quintessential to test peripartum females for latent TB, especially those belonging to endemic regions. We describe an unfortunate case of reactivation of TB in a postpartum female from Central America.

Citing Articles

Reactivated disseminated tuberculosis in pregnancy: Case report and review of the literature.

Beshar I, Moon A, Pendse R, Nevins A, Litkouhi B Case Rep Womens Health. 2022; 37:e00475.

PMID: 36582263 PMC: 9792344. DOI: 10.1016/j.crwh.2022.e00475.

Pelvic and central nervous system tuberculosis complicated by a paradoxical response manifesting as a spinal tuberculoma: a case report.

Zandvakili A, Kobayashi T, Kaewpoowat Q, Parsons M, Ford B, Barker J BMC Infect Dis. 2022; 22(1):750.

PMID: 36153478 PMC: 9509540. DOI: 10.1186/s12879-022-07731-6.

Tuberculosis in pregnancy.

Hui S, Lao T Best Pract Res Clin Obstet Gynaecol. 2022; 85(Pt A):34-44.

PMID: 36002371 PMC: 9339097. DOI: 10.1016/j.bpobgyn.2022.07.006.

References

Owusu-Edusei K, Marks S, Miramontes R, Stockbridge E, Winston C . Tuberculosis hospitalization expenditures per patient from private health insurance claims data, 2010-2014. Int J Tuberc Lung Dis. 2017; 21(4):398-404. PMC: 5810924. DOI: 10.5588/ijtld.16.0587. View

Elenkov I, Wilder R, Bakalov V, Link A, Dimitrov M, Fisher S . IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab. 2001; 86(10):4933-8. DOI: 10.1210/jcem.86.10.7905. View

Singh N, Perfect J . Immune reconstitution syndrome and exacerbation of infections after pregnancy. Clin Infect Dis. 2007; 45(9):1192-9. DOI: 10.1086/522182. View

Poole J, Claman H . Immunology of pregnancy. Implications for the mother. Clin Rev Allergy Immunol. 2004; 26(3):161-70. DOI: 10.1385/CRIAI:26:3:161. View

Ormerod P . Tuberculosis in pregnancy and the puerperium. Thorax. 2001; 56(6):494-9. PMC: 1746062. DOI: 10.1136/thorax.56.6.494. View

Zenner D, Kruijshaar M, Andrews N, Abubakar I . Risk of tuberculosis in pregnancy: a national, primary care-based cohort and self-controlled case series study. Am J Respir Crit Care Med. 2011; 185(7):779-84. DOI: 10.1164/rccm.201106-1083OC. View

Auguste P, Tsertsvadze A, Pink J, Court R, Seedat F, Gurung T . Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation. Health Technol Assess. 2016; 20(38):1-678. PMC: 4904187. DOI: 10.3310/hta20380. View

Cheng V, Woo P, Lau S, Cheung C, Yung R, Yam L . Peripartum tuberculosis as a form of immunorestitution disease. Eur J Clin Microbiol Infect Dis. 2003; 22(5):313-7. DOI: 10.1007/s10096-003-0927-1. View

Ralot T, Bafna C, Singh S, Sharma S . A Rare Presentation of Tubercular Meningitis as Persistent Neutrophilic Meningitis. Malays J Med Sci. 2018; 24(6):103-106. PMC: 5771522. DOI: 10.21315/mjms2017.24.6.13. View

10.

Marx G, Chan E . Tuberculous meningitis: diagnosis and treatment overview. Tuberc Res Treat. 2012; 2011:798764. PMC: 3335590. DOI: 10.1155/2011/798764. View

11.

Casadevall A, Pirofski L . The damage-response framework of microbial pathogenesis. Nat Rev Microbiol. 2004; 1(1):17-24. PMC: 7097162. DOI: 10.1038/nrmicro732. View

12.

El-Messidi A, Czuzoj-Shulman N, Spence A, Abenhaim H . Medical and obstetric outcomes among pregnant women with tuberculosis: a population-based study of 7.8 million births. Am J Obstet Gynecol. 2016; 215(6):797.e1-797.e6. DOI: 10.1016/j.ajog.2016.08.009. View

13.

Covelli H, Wilson R . Immunologic and medical considerations in tuberculin-sensitized pregnant patients. Am J Obstet Gynecol. 1978; 132(3):256-9. DOI: 10.1016/0002-9378(78)90889-x. View

14.

Connolly M, Nunn P . Women and tuberculosis. World Health Stat Q. 1996; 49(2):115-9. View