Tear ATG5 As a Potential Novel Biomarker in the Diagnosis of Sjögren Syndrome

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2021 Jan 7

PMID 33406739

Citations 3

Authors

Yong-Soo Byun

Hyun Jung Lee

Soojung Shin

Moon Young Choi

Hyung-Seung Kim

So-Hyang Chung

Affiliations

Soon will be listed here.

Abstract

Autophagy has been suggested to have an important role in the pathogenesis of Sjögren syndrome (SS). We previously identified that autophagy related 5 (ATG5) was elevated in the tear and conjunctival epithelial cells of SS dry eyes (DE) compared to non-SS DE. The purpose of this study was to investigate the role of tear ATG5 as a potential biomarker in the diagnosis of SS. To confirm this hypothesis, we evaluated the tear ATG5 concentration, and other ocular tests (Schirmer I, tear breakup time (TBUT), ocular surface staining (OSS) score, ocular surface disease index (OSDI)) in SS and non-DE, and compared their diagnostic performance to discriminate SS from non-SS DE. Tear ATG5 showed the greatest area under the curve (AUC = 0.984; 95% CI, 0.930 to 0.999) among the tests, and a 94.6% sensitivity and 93.6% specificity at a cutoff value of >4.0 ng/mL/μg. Our data demonstrated that tear ATG5 may be helpful as an ocular biomarker to diagnose and assess SS. In the future, the diagnostic power of tear ATG for SS should be validated.

Citing Articles

The Effect of Mesenchymal Stem Cells on Dry Eye in Sjogren Syndrome Mouse Model.

Shin S, Yoon S, Kim M, Cheon E, Jeon Y, Lee H Int J Mol Sci. 2023; 24(2).

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Exosomes and autophagy in ocular surface and retinal diseases: new insights into pathophysiology and treatment.

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