ADP-Ribosylation Factor Like GTPase 4C (ARL4C) Augments Stem-like Traits of Glioblastoma Cells by Upregulating ALDH1A3

Overview

Journal J Cancer

Specialty Oncology

Date 2021 Jan 6

PMID 33403039

Citations 5

Authors

Qian Chen

Wen-Juan Fu

Xiao-Peng Tang

Lu Wang

Qin Niu

Shuai Wang

Yong Lin

Mian-Fu Cao

Rong Hu

Hai-Yan Wen

Yan Wang

Xia Zhang

Xiao-Hong Yao

Affiliations

Soon will be listed here.

Abstract

Glioma cells with stem cell-like properties are crucial for tumor initiation, progression and therapeutic resistance. Therefore, identifying specific factors in regulating stem-like traits is critical for the design of novel glioma therapeutics. Herein, we reported that ADP-Ribosylation Factor Like GTPase 4C (ARL4C) was highly expressed in glioma stem-like cells (GSLCs). GSLCs, determined by the efficiency of sphere formation and tumor growth , was increased by overexpression of ARL4C. ARL4C induced the tumorigenesis through ALDH1A3. Analyses of 325 patient specimens showed that ARL4C was highly expressed in glioblastoma (GBM) as compared with lower grade gliomas. In addition, higher level ARL4C expression in glioma was correlated with poorer progression-free survival and overall survival of patients. Therefore, ARL4C may act as a novel prognostic marker and a therapeutic target for GBM.

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