DNA Methylation Studies in Cattle

Overview

Journal J Appl Genet

Publisher Springer

Specialty Genetics

Date 2021 Jan 5

PMID 33400132

Citations 7

Authors

Jana Haluskova

Beata Holeckova

Jana Stanicova

Affiliations

Soon will be listed here.

Abstract

Investigation of the role of epigenetics in cattle breeding is gaining importance. DNA methylation represents an epigenetic modification which is essential for genomic stability and maintenance of development. Recently, DNA methylation research in cattle has intensified. The studies focus on the definition of methylomes in various organs and tissues in relation to the expression of genes underlying economically important traits, and explore methylome changes under developmental, environmental, disease, and diet influences. The investigations further characterize the methylation patterns of gametes in connection with their quality, and study methylome alterations in the developing naturally or assisted produced zygotes, embryos, and fetuses, considering their viability. A wide array of technologies developed for accurate and precise analysis of DNA methylation patterns is employed for both single-gene and genome-wide studies. Overall, the research is directed towards the identification of single methylation markers or their combinations which may be useful in the selection and breeding of animals to ensure cattle improvement.

Citing Articles

Green forage impacts on the DNA methylation in the ruminal wall of Italian mediterranean dairy buffaloes.

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Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine.

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Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans.

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Heat-Stress Impacts on Developing Bovine Oocytes: Unraveling Epigenetic Changes, Oxidative Stress, and Developmental Resilience.

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Elucidating the Role of Transcriptomic Networks and DNA Methylation in Collagen Deposition of Dezhou Donkey Skin.

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