Genetic Characterization of -acetyltransferase 2 Variants in Acquired Multidrug-resistant Tuberculosis in Indonesia

Owing to the high resistance rate of tuberculosis (TB) to isoniazid, which is metabolized by -acetyltransferase 2 (NAT2), we investigated the associations between variants and multidrug-resistant (MDR)-TB. The acetylator status based on haplotypes of 128 patients with MDR-TB in Indonesia were compared with our published data from patients with anti-TB drug-induced liver injury (AT-DILI), TB and the general population. was more frequent in the MDR-TB group than in the AT-DILI group, TB controls and general controls. was significantly more frequent in patients with MDR-TB than in those with AT-DILI.  and were detected at lower frequencies in patients with AT-DILI. Rapid acetylators were significantly more frequent in patients with MDR-TB than in those with AT-DILI. These results provide an initial data for optimizing TB treatment in the Indonesian population, and suggest that genotyping may help to select appropriate treatment by predicting TB-treatment effect.