Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions

Overview

Journal Ann Biomed Eng

Specialty Biomedical Engineering

Date 2021 Jan 5

PMID 33398618

Citations 2

Authors

Ryan Pewowaruk

Luke Lamers

Alejandro Roldan-Alzate

Affiliations

Soon will be listed here.

Abstract

Branch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the pulmonary arteries (PAs) remodel their lumen diameter to maintain constant wall shear stress (WSS). We quantified the longitudinal progression of PA WSS in a swine model of unilateral PAS and two different intervention time courses to test this hypothesis. To quantify WSS in the entire pulmonary tree we used 4D Flow MRI for the large-proximal PAs and a structured tree model for the small-distal PAs. Our results only partially supported the hypothesis that in branch PAS the PAs remodel their lumen diameter to maintain WSS homeostasis. Proximal PA WSS was similar between groups at the final study time-point but WSS of mid-sized (5 mm to 500 μm) PA segments was found to be different between the sham and LPAS groups. This suggests that WSS homeostasis may only be achieved for the large-proximal PAs. Additionally, our results do not show WSS homeostasis being achieved over shorter periods of time suggesting that any potential WSS dependent changes in PA lumen diameter were a long-term remodeling response rather than a short-term vasodilation response. Future studies should confirm if these findings hold true in humans and investigate the impacts of WSS at different levels of the pulmonary tree on growth.

Citing Articles

Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH).

Wieland I, Diekmann F, Carlens J, Hinze L, Lambeck K, Jack T Front Pediatr. 2022; 10:1012738.

PMID: 36452355 PMC: 9701817. DOI: 10.3389/fped.2022.1012738.

Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine.

Pewowaruk R, Ralphe J, Lamers L, Roldan-Alzate A Cardiovasc Eng Technol. 2021; 12(5):494-504.

PMID: 34008077 PMC: 9513752. DOI: 10.1007/s13239-021-00543-w.

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