TARM1 Contributes to Development of Arthritis by Activating Dendritic Cells Through Recognition of Collagens

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Jan 5

PMID 33397982

Citations 7

Authors

Rikio Yabe

Soo-Hyun Chung

Masanori A Murayama

Sachiko Kubo

Kenji Shimizu

Yukiko Akahori

Takumi Maruhashi

Akimasa Seno

Tomonori Kaifu

Shinobu Saijo

Yoichiro Iwakura

Affiliations

Soon will be listed here.

Abstract

TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages and neutrophils in vitro by associating with FcRγ. However, the function of this molecule in the regulation of the immune system is unclear. Here, we show that Tarm1 expression is elevated in the joints of rheumatoid arthritis mouse models, and the development of collagen-induced arthritis (CIA) is suppressed in Tarm1 mice. T cell priming against type 2 collagen is suppressed in Tarm1 mice and antigen-presenting ability of GM-CSF-induced dendritic cells (GM-DCs) from Tarm1 mouse bone marrow cells is impaired. We show that type 2 collagen is a functional ligand for TARM1 on GM-DCs and promotes DC maturation. Furthermore, soluble TARM1-Fc and TARM1-Flag inhibit DC maturation and administration of TARM1-Fc blocks the progression of CIA in mice. These results indicate that TARM1 is an important stimulating factor of dendritic cell maturation and could be a good target for the treatment of autoimmune diseases.

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