Immune Cell-Stromal Circuitry in Lupus Photosensitivity

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2021 Jan 5

PMID 33397744

Citations 7

Authors

Ji Hyun Sim

William G Ambler

Isabel F Sollohub

Mir J Howlader

Thomas M Li

Henry J Lee

Theresa T Lu

Affiliations

Soon will be listed here.

Abstract

Photosensitivity is a sensitivity to UV radiation (UVR) commonly found in systemic lupus erythematosus (SLE) patients who have cutaneous disease. Upon even ambient UVR exposure, patients can develop inflammatory skin lesions that can reduce the quality of life. Additionally, UVR-exposed skin lesions can be associated with systemic disease flares marked by rising autoantibody titers and worsening kidney disease. Why SLE patients are photosensitive and how skin sensitivity leads to systemic disease flares are not well understood, and treatment options are limited. In recent years, the importance of immune cell-stromal interactions in tissue function and maintenance is being increasingly recognized. In this review, we discuss SLE as an anatomic circuit and review recent findings in the pathogenesis of photosensitivity with a focus on immune cell-stromal circuitry in tissue health and disease.

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