MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 5

PMID 33396834

Citations 33

Authors

Alice Chiara Manetti

Aniello Maiese

Marco DI Paolo

Alessandra De Matteis

Raffaele La Russa

Emanuela Turillazzi

Paola Frati

Vittorio Fineschi

Affiliations

Soon will be listed here.

Abstract

Sepsis is a severe condition characterized by systemic inflammation. One of the most involved organs in sepsis is the heart. On the other hand, heart failure and dysfunction are some of the most leading causes of death in septic patients. miRNAs are short single-strand non-coding ribonucleic acids involved in the regulation of gene expression on a post-transcriptional phase, which means they are a part of the epigenetic process. Recently, researchers have found that miRNA expression in tissues and blood differs depending on different conditions. Because of this property, their use as serum sepsis biomarkers has also been explored. A narrative review is carried out to gather and summarize what is known about miRNAs' influence on cardiac dysfunction during sepsis. When reviewing the literature, we found at least 77 miRNAs involved in cardiac inflammation and dysfunction during sepsis. In the future, miRNAs may be used as early sepsis-induced cardiac dysfunction biomarkers or as new drug targets. This could help clinicians to early detect, prevent, and treat cardiac damage. The potential role of miRNAs as new diagnostic tools and therapeutic strategies worth deepening the complex network between non-coding RNA and biological pathways. Additional studies are needed to further investigate their role in sepsis-induced myocardium injury.

Citing Articles

Postmortem analyses of myocardial microRNA expression in sepsis.

Lehto P, Skarp S, Saukko T, Sakkinen H, Syrjala H, Kerkela R Sci Rep. 2024; 14(1):29476.

PMID: 39604475 PMC: 11603066. DOI: 10.1038/s41598-024-81114-6.

miR-361-3p overexpression promotes apoptosis and inflammation by regulating the USP49/IκBα/NF-κB pathway to aggravate sepsis-induced myocardial injury.

Geng H, Qi L, You L, Feng W, Yang X, Lei M Toxicol Res (Camb). 2024; 13(6):tfae190.

PMID: 39568464 PMC: 11574052. DOI: 10.1093/toxres/tfae190.

Time of day-dependent alterations of ferroptosis in LPS-induced myocardial injury via Bmal-1/AKT/ Nrf2 in rat and H9c2 cell.

Ying-Hao P, Yu-Shan Y, Song-Yi C, Hua J, Peng Y, Xiao-Hu C Heliyon. 2024; 10(17):e37088.

PMID: 39296207 PMC: 11407985. DOI: 10.1016/j.heliyon.2024.e37088.

COVID-19: from immune response to clinical intervention.

Guo Z, Tang Y, Zhang Z, Liu J, Zhuang Y, Li T Precis Clin Med. 2024; 7(3):pbae015.

PMID: 39139990 PMC: 11319938. DOI: 10.1093/pcmedi/pbae015.

Septic Cardiomyopathy.

Lukic I, Mihic D, Canecki Varzic S, Relatic K, Zibar L, Loinjak D Rev Cardiovasc Med. 2024; 25(1):23.

PMID: 39077653 PMC: 11262393. DOI: 10.31083/j.rcm2501023.

References

Hobai I, Edgecomb J, LaBarge K, Colucci W . Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock. 2014; 43(1):3-15. PMC: 4269564. DOI: 10.1097/SHK.0000000000000261. View

An R, Feng J, Xi C, Xu J, Sun L . miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression. Oxid Med Cell Longev. 2018; 2018:7163057. PMC: 6129849. DOI: 10.1155/2018/7163057. View

Chen T, Zhu C, Ye C . LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24/XIAP. Cell Biochem Funct. 2020; 38(7):976-985. DOI: 10.1002/cbf.3524. View

Wang H, Bei Y, Shen S, Huang P, Shi J, Zhang J . miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016; 94:43-53. DOI: 10.1016/j.yjmcc.2016.03.014. View

Wang H, Meng K, Chen W, Feng D, Jia Y, Xie L . Serum miR-574-5p: a prognostic predictor of sepsis patients. Shock. 2012; 37(3):263-7. DOI: 10.1097/SHK.0b013e318241baf8. View

Kensler T, Wakabayashi N, Biswal S . Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2006; 47:89-116. DOI: 10.1146/annurev.pharmtox.46.120604.141046. View

Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, Ferracin M . MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One. 2009; 4(10):e7405. PMC: 2756627. DOI: 10.1371/journal.pone.0007405. View

Guo H, Tang L, Xu J, Lin C, Ling X, Lu C . MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction. Eur J Med Res. 2019; 24(1):37. PMC: 6878688. DOI: 10.1186/s40001-019-0396-3. View

Wang Y, Wang L, Chen C, Chu X . New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications. Mol Cancer. 2018; 17(1):22. PMC: 5804051. DOI: 10.1186/s12943-018-0766-4. View

10.

Shankar-Hari M, Lord G . How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?. Expert Rev Mol Diagn. 2014; 14(3):249-51. DOI: 10.1586/14737159.2014.899151. View

11.

Iskander K, Osuchowski M, Stearns-Kurosawa D, Kurosawa S, Stepien D, Valentine C . Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013; 93(3):1247-88. PMC: 3962548. DOI: 10.1152/physrev.00037.2012. View

12.

Angus D, Lidicker J, Clermont G, Carcillo J, Pinsky M . Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001; 29(7):1303-10. DOI: 10.1097/00003246-200107000-00002. View

13.

Singer M, Deutschman C, Seymour C, Shankar-Hari M, Annane D, Bauer M . The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8):801-10. PMC: 4968574. DOI: 10.1001/jama.2016.0287. View

14.

Epstein S, Zhou Y, Zhu J . Infection and atherosclerosis: emerging mechanistic paradigms. Circulation. 1999; 100(4):e20-8. DOI: 10.1161/01.cir.100.4.e20. View

15.

Tomita Y, Dorward H, Yool A, Smith E, Townsend A, Price T . Role of Aquaporin 1 Signalling in Cancer Development and Progression. Int J Mol Sci. 2017; 18(2). PMC: 5343835. DOI: 10.3390/ijms18020299. View

16.

Wei S, Liu Q . Long noncoding RNA MALAT1 modulates sepsis-induced cardiac inflammation through the miR-150-5p/NF-κB axis. Int J Clin Exp Pathol. 2020; 12(9):3311-3319. PMC: 6949863. View

17.

Arefian H, Heublein S, Scherag A, Brunkhorst F, Younis M, Moerer O . Hospital-related cost of sepsis: A systematic review. J Infect. 2016; 74(2):107-117. DOI: 10.1016/j.jinf.2016.11.006. View

18.

Mbaya-Moutoula E, Louvet L, Molinie R, Guerrera I, Cerutti C, Fourdinier O . A multi-omics analysis of the regulatory changes induced by miR-223 in a monocyte/macrophage cell line. Biochim Biophys Acta Mol Basis Dis. 2018; 1864(8):2664-2678. DOI: 10.1016/j.bbadis.2018.05.010. View

19.

Wang C, Yan M, Jiang H, Wang Q, Guan X, Chen J . Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-κB signaling pathway. Int Immunopharmacol. 2016; 40:300-309. DOI: 10.1016/j.intimp.2016.09.010. View

20.

Wang X, Yu Y . MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1. J Mol Histol. 2018; 49(4):411-417. DOI: 10.1007/s10735-018-9781-4. View