Common European Origin of Hepatitis E Virus in Human Population From Eastern Romania

Overview

Journal Front Public Health

Specialty Public Health

Date 2021 Jan 4

PMID 33392130

Citations 5

Authors

Daniela Porea

Adriana Anita

Andrei Vata

Danut Teodor

Luciana Crivei

Cristian Raileanu

Vasilica Gotu

Ioana Ratoi

Andreea Cozma

Dragos Anita

Luanda Oslobanu

Nicole Pavio

Gheorghe Savuta

Affiliations

Soon will be listed here.

Abstract

The purpose of this research was to improve the epidemiological data on HEV infection in the human population in Romania. The analysis targeted hospitalized subjects with acute hepatitis ( = 94) of unknown etiology from the Infectious Diseases Regional Hospital in Iasi. Moreover, patients without liver disease ( = 40) from a different county hospital located in Eastern Romania were included. The presence of HEV infection and first characterization of human HEV strains was determined using serological and molecular assays. The apparent HEV seroprevalence varied between 29.16% (95% CI, 16.31-42.03) and 32.5% (95% CI, 17.98-47.02) according to patient grouping. Molecular analysis enhanced the detection of two HEV isolates, that clustered in subtype HEV-3c, the most commonly identified subtype in Europe. Identification of acute hepatitis E cases, together with the first detection and molecular characterization of human HEV in Romania represent the originality attributes of the present study.

Citing Articles

An Assessment of West Nile and Usutu Viruses' Seroprevalence in Hospitalized Patients: A Preliminary Study on Flavivirus Exposure in Eastern Romania.

Crivei L, Vata A, Teodor D, Porea D, Cozma A, Anita A Pathogens. 2024; 13(2).

PMID: 38392871 PMC: 10892458. DOI: 10.3390/pathogens13020133.

First Detection of Hepatitis E Virus ( Genotype C1) in Synanthropic Norway Rats () in Romania.

Porea D, Raileanu C, Crivei L, Gotu V, Savuta G, Pavio N Viruses. 2023; 15(6).

PMID: 37376636 PMC: 10302290. DOI: 10.3390/v15061337.

Characterization of a Near Full-Length Hepatitis E Virus Genome of Subtype 3c Generated from Naturally Infected South African Backyard Pigs.

Chauhan R, Gordon M Pathogens. 2022; 11(9).

PMID: 36145462 PMC: 9506134. DOI: 10.3390/pathogens11091030.

Seroprevalence of Anti-Hepatitis E Virus Antibodies among Patients from a Tertiary Hospital from Northeast Romania.

Mihai I, Anita D, Dorneanu O, Luca C, Manciuc C, Budacu C Medicina (Kaunas). 2022; 58(8).

PMID: 36013487 PMC: 9414562. DOI: 10.3390/medicina58081020.

Hepatitis E Virus in Croatia in the "One-Health" Context.

Mrzljak A, Jemersic L, Savic V, Balen I, Ilic M, Jurekovic Z Pathogens. 2021; 10(6).

PMID: 34199798 PMC: 8227679. DOI: 10.3390/pathogens10060699.

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