Inflammation, Oxidative Stress, and Bone in Chronic Kidney Disease in the Osteoimmunology Era

Overview

Journal Calcif Tissue Int

Specialty Pathology

Date 2021 Jan 3

PMID 33388898

Citations 10

Authors

Sandro Mazzaferro

Domenico Bagordo

Natalia de Martini

Marzia Pasquali

Silverio Rotondi

Lida Tartaglione

Peter Stenvinkel

Affiliations

Soon will be listed here.

Abstract

Bone is not only a mineralized and apparently non-vital structure that provides support for locomotion and protection to inner organs. An increasing number of studies are unveiling new biologic functions and connections to other systems, giving the rise to new fields of research, such as osteoimmunology. The bone marrow niche, a new entity in bone physiology, seems to represent the site where a complex crosstalk between bone and immune/inflammatory responses takes place. An impressive interplay with the immune system is realized in bone marrow, with reciprocal influences between bone cells and haematopoietic cells. In this way, systemic chronic inflammatory diseases realize a crosstalk with bone, resulting in bone disease. Thus, pathogenetic links between chronic kidney disease-mineral bone disorders and osteoporosis, cardiovascular disease, and ageing are common. The aim of this narrative review is to provide a general view of the progresses in the field of bone research and their potential clinical implications, with emphasis on the links with inflammation and the connections to osteoimmunology and chemokines.

Citing Articles

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Bone marrow-derived exosomes promote inflammation and osteoclast differentiation in high-turnover renal osteodystrophy.

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