Endovascular Approaches in Pediatric Interventional Oncology

Overview

Journal CVIR Endovasc

Date 2021 Jan 2

PMID 33387076

Citations 3

Authors

Raja Shaikh

Fernando Gomez Munoz

Affiliations

Soon will be listed here.

Abstract

The demand for interventional oncological (IO) treatment of pediatric cancers is becoming increasingly common, at least at several tertiary care institutions. The data and techniques used in pediatric IO are largely extrapolated from experience in adult patients. The management of pediatric tumors differs from that in adults in several categories, such as, the curative intent of treatment, wide use of general anesthesia, aggressive pain management, potentially longer hospital stay, variation in chemotherapy dosing etc. Additionally, pediatric cancers are managed by protocols directed by national and international oncology groups such as the Children's Oncology Group (COG). Consequently, the translation and adoption of these techniques is gradual, but there is a noticeable uptrend due to the growing need. This review will update the current endovascular IO treatments for common pediatric liver, renal, bone and soft tissue tumors.

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References

Leahey A . A cautionary tale: dosing chemotherapy in infants with retinoblastoma. J Clin Oncol. 2012; 30(10):1023-4. DOI: 10.1200/JCO.2011.39.4254. View

Li J, Chu J, Yang J, Chen W, Wang Y, Huang Y . Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children. Cardiovasc Intervent Radiol. 2008; 31(6):1117-23. DOI: 10.1007/s00270-008-9373-x. View

Terraz S, Ronot M, Breguet R, Anooshiravani M, Rubbia-Brandt L, Becker C . Portal Vein Embolization Before Extended Hepatectomy in a Toddler With Mesenchymal Hamartoma. Pediatrics. 2015; 136(4):e1055-9. DOI: 10.1542/peds.2015-0179. View

Mutabagani K, Klopfenstein K, Hogan M, Caniano D . Metastatic paraganglioma and paraneoplastic-induced anemia in an adolescent: treatment with hepatic arterial chemoembolization. J Pediatr Hematol Oncol. 1999; 21(6):544-7. View

Rossi G, Rimondi E, Bartalena T, Gerardi A, Alberghini M, Staals E . Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate. Skeletal Radiol. 2009; 39(2):161-7. DOI: 10.1007/s00256-009-0757-z. View

Kishore S, Friedman T, Madoff D . Update on Embolization Therapies for Hepatocellular Carcinoma. Curr Oncol Rep. 2017; 19(6):40. DOI: 10.1007/s11912-017-0597-2. View

Abramson D, Dunkel I, Brodie S, Kim J, Gobin Y . A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results. Ophthalmology. 2008; 115(8):1398-404, 1404.e1. DOI: 10.1016/j.ophtha.2007.12.014. View

Yamada K, Shinmoto H, Kawamura Y, Wakamatsu H, Kawauchi T, Soga S . Transarterial embolization for pediatric hepatocellular carcinoma with cardiac cirrhosis. Pediatr Int. 2015; 57(4):766-70. DOI: 10.1111/ped.12619. View

Jha R, Sharma R, Rastogi S, Khan S, Jayaswal A, Gamanagatti S . Preoperative embolization of primary bone tumors: A case control study. World J Radiol. 2016; 8(4):378-89. PMC: 4840195. DOI: 10.4329/wjr.v8.i4.378. View

10.

Manjandavida F, Stathopoulos C, Zhang J, Honavar S, Shields C . Intra-arterial chemotherapy in retinoblastoma - A paradigm change. Indian J Ophthalmol. 2019; 67(6):740-754. PMC: 6552585. DOI: 10.4103/ijo.IJO_866_19. View

11.

Owen R . Embolization of musculoskeletal bone tumors. Semin Intervent Radiol. 2011; 27(2):111-23. PMC: 3036517. DOI: 10.1055/s-0030-1253510. View

12.

Allen-Rhoades W, Whittle S, Rainusso N . Pediatric Solid Tumors in Children and Adolescents: An Overview. Pediatr Rev. 2018; 39(9):444-453. DOI: 10.1542/pir.2017-0268. View

13.

Anderson H, Pointdujour-Lim R, Shields C . Treatments for Retinoblastoma Then and Now. JAMA Ophthalmol. 2016; 135(1):e164652. DOI: 10.1001/jamaophthalmol.2016.4652. View

14.

Anis O, Rimon U, Ramon J, Khaitovich B, Zilberman D, Portnoy O . Selective Arterial Embolization for Large or Symptomatic Renal Angiomyolipoma: 10 Years of Follow-up. Urology. 2019; 135:82-87. DOI: 10.1016/j.urology.2019.09.035. View

15.

Wyse E, Handa J, Friedman A, Pearl M . A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol. 2016; 46(9):1223-33. DOI: 10.1007/s00247-016-3554-6. View

16.

Avritscher R, Javadi S . Transcatheter intra-arterial limb infusion for extremity osteosarcoma: technical considerations and outcomes. Tech Vasc Interv Radiol. 2011; 14(3):124-8. DOI: 10.1053/j.tvir.2011.02.004. View

17.

Inomata M, Kaneko A . Chemosensitivity profiles of primary and cultured human retinoblastoma cells in a human tumor clonogenic assay. Jpn J Cancer Res. 1987; 78(8):858-68. View

18.

Cazejust J, De Baere T, Auperin A, Deschamps F, Hechelhammer L, Abdel-Rehim M . Transcatheter arterial chemoembolization for liver metastases in patients with adrenocortical carcinoma. J Vasc Interv Radiol. 2010; 21(10):1527-32. DOI: 10.1016/j.jvir.2010.05.020. View

19.

Lungren M, Towbin A, Roebuck D, Monroe E, Gill A, Thakor A . Role of interventional radiology in managing pediatric liver tumors : Part 1: Endovascular interventions. Pediatr Radiol. 2018; 48(4):555-564. DOI: 10.1007/s00247-018-4068-1. View

20.

Qin H, Yang S, Cai S, Ren Q, Han W, Yang W . Clinical characteristics and risk factors of 47 cases with ruptured neuroblastoma in children. BMC Cancer. 2020; 20(1):243. PMC: 7092550. DOI: 10.1186/s12885-020-06720-9. View