Alpha 2.0
Login Register
» Articles » PMID: 3338551

Prothymosin Alpha is a Nuclear Protein

Overview
Journal FEBS Lett
Specialty Biochemistry
Date 1988 Jan 4
PMID 3338551
Citations 26
Authors
J Gomez-Marquez
F Segade
Affiliations
Soon will be listed here.
Abstract

Prothymosin alpha, a protein first isolated from rat thymus and widely distributed in animal tissues, has an attributed role in the stimulation of the immune system. Its structure contains thymosin alpha 1, a Glu-rich domain and a putative nuclear location signal. Furthermore, the amount of this protein seems to be associated with the relative size of the nucleus and is inducible during cell growth. We postulate that prothymosin alpha is located inside the cell nucleus and that its activity might be to organize some protein complexes.

Citing Articles

Apoptotic and proliferating hepatocytes differ in prothymosin alpha expression and cell localization.

Barbini L, Gonzalez R, Dominguez F, Vega F Mol Cell Biochem. 2006; 291(1-2):83-91.

PMID: 16845491 DOI: 10.1007/s11010-006-9200-0.

Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation.

Subramanian C, Hasan S, Rowe M, Hottiger M, Orre R, Robertson E J Virol. 2002; 76(10):4699-708.

PMID: 11967287 PMC: 136123. DOI: 10.1128/jvi.76.10.4699-4708.2002.

Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.

Cotter 2nd M, Robertson E Mol Cell Biol. 2000; 20(15):5722-35.

PMID: 10891508 PMC: 86050. DOI: 10.1128/MCB.20.15.5722-5735.2000.

Tumour prothymosin alpha content, a potential prognostic marker for primary breast cancer.

Magdalena C, Dominguez F, Loidi L, Puente J Br J Cancer. 2000; 82(3):584-90.

PMID: 10682670 PMC: 2363325. DOI: 10.1054/bjoc.1999.0968.

Gene expression induced by physical impedance in maize roots.

Huang Y, JORDAN W, Wing R, Morgan P Plant Mol Biol. 1998; 37(6):921-30.

PMID: 9700065 DOI: 10.1023/a:1006034411529.