The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder

Overview

Journal Nutrients

Date 2021 Jan 1

PMID 33383670

Citations 6

Authors

Martina Platzer

Frederike T Fellendorf

Susanne A Bengesser

Armin Birner

Nina Dalkner

Carlo Hamm

Melanie Lenger

Alexander Maget

Rene Pilz

Robert Queissner

Bernd Reininghaus

Alexandra Reiter

Harald Mangge

Sieglinde Zelzer

Hans-Peter Kapfhammer

Eva Z Reininghaus

Affiliations

Soon will be listed here.

Abstract

Obesity and weight gain in bipolar disorder (BD) have multifactorial underlying causes such as medication side effects, atypical depressive symptomatology, genetic variants, and disturbances in the neuro-endocrinal system. Therefore, we aim to explore the associations between food craving (FC), clinical parameters, psychotropic medication, and appetite-related hormones. In this cross-sectional investigation, 139 individuals with BD and 93 healthy controls (HC) completed the food craving inventory (FCI). In addition, blood samples (including leptin and acylated ghrelin) were analyzed and sociodemographic and anthropometric data were collected. Individuals with BD reported higher frequencies of total FC as well as craving for fat and fast food than HC. Additionally, we found a significant negative correlation between FC and ghrelin levels in BD. Smokers with BD reported significantly more craving for high fat foods than non-smokers. Age was significantly associated with FC independent of group. Individuals with BD taking olanzapine and quetiapine reported higher frequencies of craving for sweet food, while patients currently taking lithium reported less total FC compared to those without lithium therapy. Likewise, patients currently taking valproate reported less total FC and less craving for sweets than those not taking valproate. FC appears to be of clinical relevance in individuals with BD. Contrary to previous data, this does not seem to be a female phenomenon only and might encompass more than the specific craving for carbohydrates. Although due to the cross sectional design, causality cannot be determined, the association between depressive symptomatology and fast food craving warrants further research.

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References

Morin V, Hozer F, Costemale-Lacoste J . The effects of ghrelin on sleep, appetite, and memory, and its possible role in depression: A review of the literature. Encephale. 2018; 44(3):256-263. DOI: 10.1016/j.encep.2017.10.012. View

Fortuna J . The obesity epidemic and food addiction: clinical similarities to drug dependence. J Psychoactive Drugs. 2012; 44(1):56-63. DOI: 10.1080/02791072.2012.662092. View

Mertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B . Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015; 527(7576):95-9. PMC: 4742055. DOI: 10.1038/nature15526. View

Gibson E . Emotional influences on food choice: sensory, physiological and psychological pathways. Physiol Behav. 2006; 89(1):53-61. DOI: 10.1016/j.physbeh.2006.01.024. View

Park H, Ahima R . Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2014; 64(1):24-34. PMC: 4267898. DOI: 10.1016/j.metabol.2014.08.004. View

Hill A . The psychology of food craving. Proc Nutr Soc. 2007; 66(2):277-85. DOI: 10.1017/S0029665107005502. View

Pepino M, Finkbeiner S, Mennella J . Similarities in food cravings and mood states between obese women and women who smoke tobacco. Obesity (Silver Spring). 2009; 17(6):1158-63. PMC: 2757734. DOI: 10.1038/oby.2009.46. View

Birner A, Platzer M, Bengesser S, Dalkner N, Fellendorf F, Queissner R . Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder. PLoS One. 2017; 12(2):e0172699. PMC: 5328271. DOI: 10.1371/journal.pone.0172699. View

Christensen L, Pettijohn L . Mood and carbohydrate cravings. Appetite. 2001; 36(2):137-45. DOI: 10.1006/appe.2001.0390. View

10.

Paykel E, Mueller P, De la Vergne P . Amitriptyline, weight gain and carbohydrate craving: a side effect. Br J Psychiatry. 1973; 123(576):501-7. DOI: 10.1192/bjp.123.5.501. View

11.

Castaneda T, Tong J, Datta R, Culler M, Tschop M . Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol. 2009; 31(1):44-60. DOI: 10.1016/j.yfrne.2009.10.008. View

12.

van der Lely A, Tschop M, Heiman M, Ghigo E . Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004; 25(3):426-57. DOI: 10.1210/er.2002-0029. View

13.

Zellner D, Rohm E, Centeno S, Parker S . Food liking and craving: A cross-cultural approach. Appetite. 1999; 33(1):61-70. DOI: 10.1006/appe.1999.0234. View

14.

Dallongeville J, Marecaux N, Fruchart J, Amouyel P . Cigarette smoking is associated with unhealthy patterns of nutrient intake: a meta-analysis. J Nutr. 1998; 128(9):1450-7. DOI: 10.1093/jn/128.9.1450. View

15.

Weingarten H, Elston D . The phenomenology of food cravings. Appetite. 1990; 15(3):231-46. DOI: 10.1016/0195-6663(90)90023-2. View

16.

McIntyre R, Danilewitz M, Liauw S, Kemp D, Nguyen H, Kahn L . Bipolar disorder and metabolic syndrome: an international perspective. J Affect Disord. 2010; 126(3):366-87. DOI: 10.1016/j.jad.2010.04.012. View

17.

Martinotti G, Montemitro C, Baroni G, Andreoli S, Alimonti F, Di Nicola M . Relationship between craving and plasma leptin concentrations in patients with cocaine addiction. Psychoneuroendocrinology. 2017; 85:35-41. DOI: 10.1016/j.psyneuen.2017.08.004. View

18.

Palaniappan U, Jacobs Starkey L, OLoughlin J, Gray-Donald K . Fruit and vegetable consumption is lower and saturated fat intake is higher among Canadians reporting smoking. J Nutr. 2001; 131(7):1952-8. DOI: 10.1093/jn/131.7.1952. View

19.

Boswell R, Kober H . Food cue reactivity and craving predict eating and weight gain: a meta-analytic review. Obes Rev. 2015; 17(2):159-77. PMC: 6042864. DOI: 10.1111/obr.12354. View

20.

Schmid D, Held K, Ising M, Uhr M, Weikel J, Steiger A . Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology. 2005; 30(6):1187-92. DOI: 10.1038/sj.npp.1300670. View