Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2020 Dec 31

PMID 33382877

Citations 9

Authors

Oana Patricia Zaharia

Dominik Hans Pesta

Pavel Bobrov

Yuliya Kupriyanova

Christian Herder

Yanislava Karusheva

Kalman Bodis

Gidon Josia Bonhof

Johannes Knitza

David Simon

Arnd Kleyer

Jong-Hee Hwang

Karsten Mussig

Dan Ziegler

Volker Burkart

Georg Schett

Michael Roden

Julia Szendroedi

Affiliations

Soon will be listed here.

Abstract

Context: Type 2 diabetes is associated with a greater risk for musculoskeletal disorders, yet its impact on joint function remains unclear.

Objective: We hypothesized that patients with type 2 diabetes and osteoarthritis would exhibit musculoskeletal impairment, which would associate with insulin resistance and distinct microRNA profiles.

Methods: Participants of the German Diabetes Study with type 2 diabetes (T2D, n = 39) or normal glucose tolerance (CON, n = 27), both with (+OA) or without osteoarthritis (-OA) underwent intravenous glucose tolerance and hyperinsulinemic-euglycemic clamp tests. Musculoskeletal function was assessed by isometric knee extension strength (KES), grip strength, range of motion (ROM), and balance skills, while neural function was measured by nerve conductance velocity (NCV). Arthritis-related symptoms were quantified using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, serum arthritis-related microRNA using quantitative polymerase chain reaction.

Results: Insulin sensitivity was lower in T2D+OA vs T2D-OA (4.4 ± 2.0 vs 5.7 ± 3.0 mg* kg-1*min-1) and in CON+OA vs CON-OA (8.1 ± 2.0 vs 12.0 ± 2.6 mg*kg-1,*min-1, both P < .05). In T2D+OA, KES and ROM were 60% and 22% lower than in CON+OA, respectively (both P < .05). Insulin sensitivity correlated positively with KES (r = 0.41, P < .05) among T2D, and negatively with symptom severity in CON and T2D (r = -0.60 and r = -0.46, respectively, P < .05). CON+OA and T2D+OA had inferior balance skills than CON-OA, whereas NCV was comparable in T2D+OA and T2D-OA. Expression of arthritis-related microRNAs was upregulated in T2D compared to CON, but downregulated in CON+OA compared to CON-OA (P < .05), and did not differ between T2D+OA and T2D-OA.

Conclusion: Musculoskeletal impairment and osteoarthritis-related symptoms are associated with insulin resistance. Type 2 diabetes can mask changes in arthritis-related microRNA profiles.

Citing Articles

Combined knee osteoarthritis and diabetes is associated with reduced muscle strength, physical inactivity, and poorer quality of life.

Seow S, Mat S, Teoh J, Mohamad Yusup A, Rajab N, Safinar Ismail I J Rehabil Med. 2024; 56:jrm39986.

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Association of the visceral fat metabolic score with osteoarthritis risk: a cross-sectional study from NHANES 2009-2018.

Xue H, Zhang L, Xu J, Gao K, Jiang L, Lv S BMC Public Health. 2024; 24(1):2269.

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Diabetes and Functional Impairment in Osteoarthritis: Investigating Correlations, Associations, and Progression.

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Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management.

Mocanu V, Timofte D, Zara-Danceanu C, Labusca L Biomedicines. 2024; 12(6).

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Association between higher triglyceride glucose index and increased risk of osteoarthritis: data from NHANES 2015-2020.

Huang J, Rozi R, Ma J, Fu B, Lu Z, Liu J BMC Public Health. 2024; 24(1):758.

PMID: 38468219 PMC: 10929152. DOI: 10.1186/s12889-024-18272-9.

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