Alleviates Colitis Via the IL-22/Occludin Signal Pathway

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2020 Dec 31

PMID 33381598

Citations 3

Authors

Xin Wang

Huai-Cai Zeng

Yan-Ru Huang

Qing-Zhi He

Affiliations

Soon will be listed here.

Abstract

Ulcerative colitis (UC) is the most common inflammatory bowel disease, and its incidence has increased in recent years. Recent clinical and experimental data indicate that gut microbiota plays a pivotal role in the pathogenesis of UC. establishes a stable and persistent colonization in the gastrointestinal tract without apparent pathogenicity to gastrointestinal or extragastrointestinal tissues. However, the detailed effects of on the gastrointestinal tissue remain unknown. The primary aim of this study is to investigate the effects of () on development of colitis induced by dextran sodium sulfate (DSS) and the underlying molecular mechanism. The results suggested that significantly improved colitis symptoms-including weight loss, disease activity index, colon length, and histopathological changes in the colon caused by DSS-and alleviated the reduced expression of interleukin-22 and occludin in the colonic tissue due to DSS administration. Furthermore, the absence of IL-22 completely prevented from alleviating colitis and significantly decreased the levels of occludin, an important downstream effector protein of IL-22. These findings suggest that ameliorates ulcerative colitis induced by DSS via the IL-22/occludin signal pathway.

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