Extracellular Vesicles in Trypanosomatids: Host Cell Communication

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2020 Dec 31

PMID 33381465

Citations 40

Authors

Ana Claudia Torrecilhas

Rodrigo Pedro Soares

Sergio Schenkman

Christopher Fernandez-Prada

Martin Olivier

Affiliations

Soon will be listed here.

Abstract

and (Trypanosomatidae: Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis and Leishmaniases worldwide. They are vector borne diseases transmitted by triatomine bugs, Tsetse fly, and sand flies, respectively. Those diseases cause enormous economic losses and morbidity affecting not only rural and poverty areas but are also spreading to urban areas. During the parasite-host interaction, those organisms release extracellular vesicles (EVs) that are crucial for the immunomodulatory events triggered by the parasites. EVs are involved in cell-cell communication and can act as important pro-inflammatory mediators. Therefore, interface between EVs and host immune responses are crucial for the immunopathological events that those diseases exhibit. Additionally, EVs from these organisms have a role in the invertebrate hosts digestive tracts prior to parasite transmission. This review summarizes the available data on how EVs from those medically important trypanosomatids affect their interaction with vertebrate and invertebrate hosts.

Citing Articles

Performance of Extracellular Vesicles From () for Serological Diagnosis of Human and Canine Visceral Leishmaniasis.

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Global Lipidomics Reveals the Lipid Composition Heterogeneity of Extracellular Vesicles from Drug-Resistant .

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Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1.

Ansa-Addo E, Pathak P, McCrossan M, Volpato Rossi I, Abdullahi M, Stratton D J Extracell Vesicles. 2024; 13(11):e70014.

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RNA-containing extracellular vesicles in infection.

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