Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Dec 31

PMID 33381123

Citations 12

Authors

Anuya Paranjape

Mindy Tsai

Kaori Mukai

Ramona A Hoh

Shilpa A Joshi

R Sharon Chinthrajah

Kari C Nadeau

Scott D Boyd

Stephen J Galli

Affiliations

Soon will be listed here.

Abstract

Basophil activation tests (BATs) can closely monitor, , a patient's propensity to develop type I hypersensitivity reactions. Because of their high specificity and sensitivity, BATs have become promising diagnostic tools, especially in cases with equivocal clinical histories, skin prick test results, and/or levels of specific IgE to allergen extracts. BATs also are useful as tools for monitoring the effects of treatment, since oral immunotherapy (OIT) studies report a diminution in patients' basophil responsiveness over the course of OIT. This review will discuss the BAT findings obtained before, during, and after OIT for food allergy. We will mainly focus on the association of basophil responsiveness, and alterations in basophil surface markers, with clinical outcomes and other clinical features, such as blood levels of specific IgG and IgE antibodies. The detailed analysis of these correlations will ultimately facilitate the use of BATs, along with other blood biomarkers, to differentiate short-term desensitization versus sustained unresponsiveness and to improve treatment protocols. Given the critical anatomic location of mast cells adjacent to the many IgE plasma cells found in the gastrointestinal tissues of allergic individuals, we will also discuss the role of gastrointestinal mast cells in manifestations of food allergies.

Citing Articles

Effect of Small-Molecule Natural Compounds on Pathologic Mast Cell/Basophil Activation in Allergic Diseases.

Werner R, Carnazza M, Li X, Yang N Cells. 2024; 13(23).

PMID: 39682741 PMC: 11639848. DOI: 10.3390/cells13231994.

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis.

Yin Y, Li J, Metcalfe D, Olivera A, Frischmeyer-Guerrerio P, Carter M J Allergy Clin Immunol Glob. 2024; 3(4):100296.

PMID: 39148513 PMC: 11325225. DOI: 10.1016/j.jacig.2024.100296.

Low-dose oral immunotherapy in immunoglobulin E-mediated food allergies.

Ma D, Zhu R Front Immunol. 2024; 15:1321863.

PMID: 38361918 PMC: 10867954. DOI: 10.3389/fimmu.2024.1321863.

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies.

Brasal-Prieto M, Fernandez-Prades L, Dakhaoui H, Sobrino F, Lopez-Enriquez S, Palomares F Nutrients. 2023; 15(17).

PMID: 37686776 PMC: 10489659. DOI: 10.3390/nu15173744.

Oral Immunotherapy in Food Allergy: Where Are We Now?.

Gokmirza Ozdemir P, Sato S, Yanagida N, Ebisawa M Allergy Asthma Immunol Res. 2023; 15(2):125-144.

PMID: 37021501 PMC: 10079524. DOI: 10.4168/aair.2023.15.2.125.

References

Jones S, Sicherer S, Burks A, Leung D, Lindblad R, Dawson P . Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J Allergy Clin Immunol. 2017; 139(4):1242-1252.e9. PMC: 8609774. DOI: 10.1016/j.jaci.2016.08.017. View

Rubio A, Vivinus-Nebot M, Bourrier T, Saggio B, Albertini M, Bernard A . Benefit of the basophil activation test in deciding when to reintroduce cow's milk in allergic children. Allergy. 2010; 66(1):92-100. DOI: 10.1111/j.1398-9995.2010.02432.x. View

Jones S, Pons L, Roberts J, Scurlock A, Perry T, Kulis M . Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009; 124(2):292-300, 300.e1-97. PMC: 2725434. DOI: 10.1016/j.jaci.2009.05.022. View

Yamaguchi M, Hirai K, Ohta K, Suzuki K, Kitani S, Takaishi T . Nonreleasing basophils convert to releasing basophils by culturing with IL-3. J Allergy Clin Immunol. 1996; 97(6):1279-87. DOI: 10.1016/s0091-6749(96)70196-3. View

Wanich N, Nowak-Wegrzyn A, Sampson H, Shreffler W . Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009; 123(4):789-94.e20. PMC: 2831768. DOI: 10.1016/j.jaci.2008.12.1128. View

Cassard L, Jonsson F, Arnaud S, Daeron M . Fcγ receptors inhibit mouse and human basophil activation. J Immunol. 2012; 189(6):2995-3006. DOI: 10.4049/jimmunol.1200968. View

Song Y, Wang J, Leung N, Wang L, Lisann L, Sicherer S . Correlations between basophil activation, allergen-specific IgE with outcome and severity of oral food challenges. Ann Allergy Asthma Immunol. 2015; 114(4):319-26. DOI: 10.1016/j.anai.2015.01.006. View

Kleine-Tebbe J, Erdmann S, Knol E, Macglashan Jr D, Poulsen L, Gibbs B . Diagnostic tests based on human basophils: potentials, pitfalls and perspectives. Int Arch Allergy Immunol. 2006; 141(1):79-90. DOI: 10.1159/000094495. View

Gane P, Pecquet C, Lambin P, Abuaf N, Leynadier F, Rouger P . Flow cytometric evaluation of human basophils. Cytometry. 1993; 14(3):344-8. DOI: 10.1002/cyto.990140316. View

10.

Zhao W, Kepley C, Morel P, Okumoto L, Fukuoka Y, Schwartz L . Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells. J Immunol. 2006; 177(1):694-701. PMC: 2176083. DOI: 10.4049/jimmunol.177.1.694. View

11.

Patil S, Steinbrecher J, Calatroni A, Smith N, Ma A, Ruiter B . Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy. J Allergy Clin Immunol. 2019; 144(5):1310-1319.e4. PMC: 6905043. DOI: 10.1016/j.jaci.2019.07.028. View

12.

Galli S, Kalesnikoff J, Grimbaldeston M, Piliponsky A, Williams C, Tsai M . Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol. 2005; 23:749-86. DOI: 10.1146/annurev.immunol.21.120601.141025. View

13.

Tsai M, Mukai K, Chinthrajah R, Nadeau K, Galli S . Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE. J Allergy Clin Immunol. 2019; 145(3):885-896.e6. PMC: 6957313. DOI: 10.1016/j.jaci.2019.10.038. View

14.

Santos A, Shreffler W . Road map for the clinical application of the basophil activation test in food allergy. Clin Exp Allergy. 2017; 47(9):1115-1124. PMC: 5601249. DOI: 10.1111/cea.12964. View

15.

Keet C, Frischmeyer-Guerrerio P, Thyagarajan A, Schroeder J, Hamilton R, Boden S . The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol. 2011; 129(2):448-55, 455.e1-5. PMC: 3437605. DOI: 10.1016/j.jaci.2011.10.023. View

16.

MacGinnitie A, Rachid R, Gragg H, Little S, Lakin P, Cianferoni A . Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2016; 139(3):873-881.e8. PMC: 5369605. DOI: 10.1016/j.jaci.2016.08.010. View

17.

Varricchi G, Raap U, Rivellese F, Marone G, Gibbs B . Human mast cells and basophils-How are they similar how are they different?. Immunol Rev. 2018; 282(1):8-34. DOI: 10.1111/imr.12627. View

18.

Korosec P, Gibbs B, Rijavec M, Custovic A, Turner P . Important and specific role for basophils in acute allergic reactions. Clin Exp Allergy. 2018; 48(5):502-512. PMC: 5947573. DOI: 10.1111/cea.13117. View

19.

Renz H, Allen K, Sicherer S, Sampson H, Lack G, Beyer K . Food allergy. Nat Rev Dis Primers. 2018; 4:17098. DOI: 10.1038/nrdp.2017.98. View

20.

Knol E, Mul F, Kuijpers T, Verhoeven A, Roos D . Intracellular events in anti-IgE nonreleasing human basophils. J Allergy Clin Immunol. 1992; 90(1):92-103. DOI: 10.1016/s0091-6749(06)80015-1. View