Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2020 Dec 31

PMID 33381020

Citations 11

Authors

Joy Q He

Eric S Sussman

Gary K Steinberg

Affiliations

Soon will be listed here.

Abstract

Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem cell transplantation-based therapies have emerged as potential restorative therapies. Aligning with the major cell types found within the ischemic brain, stem-cell-based clinical trials for ischemic stroke have fallen under three broad cell lineages: hematopoietic, mesenchymal, and neural. In this review article, we will discuss the scientific rationale for transplanting cells from each of these lineages and provide an overview of published and ongoing trials using this framework.

Citing Articles

Brain repair mechanisms after cell therapy for stroke.

Rust R, Nih L, Liberale L, Yin H, El Amki M, Ong L Brain. 2024; 147(10):3286-3305.

PMID: 38916992 PMC: 11449145. DOI: 10.1093/brain/awae204.

Estimation of the Ischemic Lesion in the Experimental Stroke Studies Using Magnetic Resonance Imaging (Review).

Namestnikova D, Cherkashova E, Gumin I, Chekhonin V, Yarygin K, Gubskiy I Bull Exp Biol Med. 2024; 176(5):649-657.

PMID: 38733482 DOI: 10.1007/s10517-024-06086-z.

Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy.

Wang S, He Q, Qu Y, Yin W, Zhao R, Wang X Neural Regen Res. 2024; 19(11):2430-2443.

PMID: 38526280 PMC: 11090435. DOI: 10.4103/1673-5374.391313.

Comparative study of the efficacy of intra-arterial and intravenous transplantation of human induced pluripotent stem cells-derived neural progenitor cells in experimental stroke.

Cherkashova E, Namestnikova D, Leonov G, Gubskiy I, Sukhinich K, Melnikov P PeerJ. 2023; 11:e16358.

PMID: 38025691 PMC: 10640846. DOI: 10.7717/peerj.16358.

Mesenchymal stem cells in ischemic tissue regeneration.

Szydlak R World J Stem Cells. 2023; 15(2):16-30.

PMID: 36909782 PMC: 9993139. DOI: 10.4252/wjsc.v15.i2.16.

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