Long Sleep Duration and Cardiovascular Disease: Associations with Arterial Stiffness and Blood Pressure Variability

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2020 Dec 30

PMID 33377597

Citations 13

Authors

Hideaki Matsubayashi

Michiaki Nagai

Keigo Dote

Yuda Turana

Saulat Siddique

Yook-Chin Chia

Chen-Huan Chen

Hao-Min Cheng

Huynh Van Minh

Narsingh Verma

Jam Chin Tay

Boon Wee Teo

Kazuomi Kario

Affiliations

Soon will be listed here.

Abstract

Although short and long sleep duration are both risk factors of cardiovascular disease (CVD), the recent meta-analyses have been shown that long sleep duration was closely associated with CVD mortality. While the specific mechanism underlying the association between long sleep duration and CVD remains unclear, long sleep duration was shown to be associated with arterial stiffness and blood pressure variability (BPV) in many Asian populations. This review article will focus on the pathophysiology of long sleep duration, arterial stiffness, BPV and their effects on CVD. To set the stage for this review, we first summarize the current insights for the relationship between long sleep duration and CVD in relation to arterial stiffness and BPV.

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References

Tsai T, Wu J, Yang Y, Huang Y, Lu F, Chang C . Long sleep duration associated with a higher risk of increased arterial stiffness in males. Sleep. 2014; 37(8):1315-20. PMC: 4096200. DOI: 10.5665/sleep.3920. View

Hoshide S, Yano Y, Mizuno H, Kanegae H, Kario K . Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure). Hypertension. 2017; 71(1):177-184. DOI: 10.1161/HYPERTENSIONAHA.117.10385. View

Johansson J, Kronholm E, Jula A . Variability in home-measured blood pressure and heart rate: associations with self-reported insomnia and sleep duration. J Hypertens. 2011; 29(10):1897-905. DOI: 10.1097/HJH.0b013e32834abccd. View

Logan J, Kang H, Lobo J, Sohn M, Lin G, Lima J . Actigraphy-based sleep characteristics and aortic stiffness: the Multi-Ethnic Study of Atherosclerosis. J Am Soc Hypertens. 2018; 12(12):841-849. PMC: 6503666. DOI: 10.1016/j.jash.2018.09.008. View

Wingard D, Berkman L . Mortality risk associated with sleeping patterns among adults. Sleep. 1983; 6(2):102-7. DOI: 10.1093/sleep/6.2.102. View

Omboni S, Parati G, Di Rienzo M, Wieling W, Mancia G . Blood pressure and heart rate variability in autonomic disorders: a critical review. Clin Auton Res. 1996; 6(3):171-82. DOI: 10.1007/BF02281905. View

Stamatakis K, Punjabi N . Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest. 2009; 137(1):95-101. PMC: 2803120. DOI: 10.1378/chest.09-0791. View

Ishihara K, Miyasita A, Inugami M, Fukuda K, Miyata Y . Differences in sleep-wake habits and EEG sleep variables between active morning and evening subjects. Sleep. 1987; 10(4):330-42. DOI: 10.1093/sleep/10.4.330. View

Kingwell B, Cameron J, Gillies K, Jennings G, Dart A . Arterial compliance may influence baroreflex function in athletes and hypertensives. Am J Physiol. 1995; 268(1 Pt 2):H411-8. DOI: 10.1152/ajpheart.1995.268.1.H411. View

10.

Full K, Malhotra A, Gallo L, Kerr J, Arredondo E, Natarajan L . Accelerometer-Measured Sleep Duration and Clinical Cardiovascular Risk Factor Scores in Older Women. J Gerontol A Biol Sci Med Sci. 2019; 75(9):1771-1778. PMC: 7494034. DOI: 10.1093/gerona/glz201. View

11.

Niijima S, Nagai M, Hoshide S, Takahashi M, Shimpo M, Kario K . Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: the J-HOP study. J Am Soc Hypertens. 2016; 10(5):429-37. DOI: 10.1016/j.jash.2016.02.010. View

12.

Kripke D, Simons R, GARFINKEL L, HAMMOND E . Short and long sleep and sleeping pills. Is increased mortality associated?. Arch Gen Psychiatry. 1979; 36(1):103-16. DOI: 10.1001/archpsyc.1979.01780010109014. View

13.

Krittanawong C, Tunhasiriwet A, Wang Z, Zhang H, Farrell A, Chirapongsathorn S . Association between short and long sleep durations and cardiovascular outcomes: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. 2017; 8(8):762-770. DOI: 10.1177/2048872617741733. View

14.

Ge L, Guyatt G, Tian J, Pan B, Chang Y, Chen Y . Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies. Sleep Med Rev. 2019; 48:101215. DOI: 10.1016/j.smrv.2019.101215. View

15.

Rothwell P, Howard S, Dolan E, OBrien E, Dobson J, Dahlof B . Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010; 375(9718):895-905. DOI: 10.1016/S0140-6736(10)60308-X. View

16.

Mattace-Raso F, van der Cammen T, van der Meer I, Schalekamp M, Asmar R, Hofman A . C-reactive protein and arterial stiffness in older adults: the Rotterdam Study. Atherosclerosis. 2004; 176(1):111-6. DOI: 10.1016/j.atherosclerosis.2004.04.014. View

17.

Partinen M, Putkonen P, Kaprio J, Koskenvuo M, Hilakivi I . Sleep disorders in relation to coronary heart disease. Acta Med Scand Suppl. 1982; 660:69-83. DOI: 10.1111/j.0954-6820.1982.tb00362.x. View

18.

Liu X, Song Q, Wu S, Wang X . Long sleep duration and risk of increased arterial stiffness in a Chinese population. Medicine (Baltimore). 2020; 99(36):e22073. PMC: 7478423. DOI: 10.1097/MD.0000000000022073. View

19.

Miwa K, Tanaka M, Okazaki S, Yagita Y, Sakaguchi M, Mochizuki H . Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors. Neurology. 2014; 83(7):646-53. DOI: 10.1212/WNL.0000000000000692. View

20.

Stranges S, Dorn J, Shipley M, Kandala N, Trevisan M, Miller M . Correlates of short and long sleep duration: a cross-cultural comparison between the United Kingdom and the United States: the Whitehall II Study and the Western New York Health Study. Am J Epidemiol. 2008; 168(12):1353-64. PMC: 2727192. DOI: 10.1093/aje/kwn337. View