The Role of Urine F2-ISOPROSTANE CONcentration in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Haemorrhage-A Poor Prognostic Factor

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2020 Dec 30

PMID 33375060

Citations 3

Authors

Karol Wisniewski

Marta Popeda

Bartlomiej Tomasik

Michal Bienkowski

Ernest J Bobeff

Ludomir Stefanczyk

Krzysztof Tybor

Marlena Hupalo

Dariusz J Jaskolski

Affiliations

Soon will be listed here.

Abstract

The pathophysiology of delayed cerebral ischemia (DCI) remains unclear. One of the hypotheses suggests that reactive oxygen species play a role in its onset. Thus, we studied F2-isoprostanes (F2-IsoPs)-oxidative stress biomarkers. Our goal was to improve the early diagnosis of DCI in a non-invasive way. We conducted a prospective single center analysis of 38 aneurysmal subarachnoid hemorrhage patients. We assessed urine F2-IsoP concentration using immunoenzymatic arrays between the first and fifth day after bleeding. A correlation between urine F2-IsoP concentration and DCI occurrence was examined regarding clinical conditions and outcomes. The urine F2-IsoP concentrations were greater than those in the control groups ( < 0.001). The 3rd day urine F2-IsoPs concentrations were correlated with DCI occurrence ( < 0.001) and long term outcomes after 12 months ( < 0.001). High levels of urine F2-IsoPs on day 3 can herald DCI.

Citing Articles

Biomarkers in aneurysmal subarachnoid hemorrhage: A short review.

Batista S, Bocanegra-Becerra J, Claassen B, Rubiao F, Rabelo N, Figueiredo E World Neurosurg X. 2023; 19:100205.

PMID: 37206060 PMC: 10189293. DOI: 10.1016/j.wnsx.2023.100205.

Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review.

Tjerkstra M, Labib H, Coert B, Spijker R, Coutinho J, Vandertop W J Circ Biomark. 2023; 12:17-25.

PMID: 37056917 PMC: 10087563. DOI: 10.33393/jcb.2023.2502.

Plasma Amino Acids May Improve Prediction Accuracy of Cerebral Vasospasm after Aneurysmal Subarachnoid Haemorrhage.

Bobeff E, Bukowiecka-Matusiak M, Stawiski K, Wisniewski K, Burzynska-Pedziwiatr I, Kordzinska M J Clin Med. 2022; 11(2).

PMID: 35054073 PMC: 8779950. DOI: 10.3390/jcm11020380.

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