Altered Ca Homeostasis in Immune Cells During Aging: Role of Ion Channels

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Dec 30

PMID 33374304

Citations 10

Authors

Dorina Zophel

Chantal Hof

Annette Lis

Affiliations

Soon will be listed here.

Abstract

Aging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density but also at varying ages and with different speed. Therefore, aging can also be understood as an adaptation to a continually changing cellular environment. One of these very prominent changes in age affects Ca signaling. Especially immune cells highly rely on Ca-dependent processes and a strictly regulated Ca homeostasis. The intricate patterns of impaired immune cell function may represent a deficit or compensatory mechanisms. Besides, altered immune function through Ca signaling can profoundly affect the development of age-related disease. This review attempts to summarize changes in Ca signaling due to channels and receptors in T cells and beyond in the context of aging.

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References

Komiya Y, Runnels L . TRPM channels and magnesium in early embryonic development. Int J Dev Biol. 2015; 59(7-9):281-8. PMC: 4685952. DOI: 10.1387/ijdb.150196lr. View

Hogan P, Chen L, Nardone J, Rao A . Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 2003; 17(18):2205-32. DOI: 10.1101/gad.1102703. View

Grubeck-Loebenstein B, Berger P, Saurwein-Teissl M, Zisterer K, Wick G . No immunity for the elderly. Nat Med. 1998; 4(8):870. DOI: 10.1038/nm0898-870b. View

Gwack Y, Srikanth S, Oh-Hora M, Hogan P, Lamperti E, Yamashita M . Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008; 28(17):5209-22. PMC: 2519726. DOI: 10.1128/MCB.00360-08. View

Beeton C, Chandy K . Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist. 2005; 11(6):550-62. DOI: 10.1177/1073858405278016. View

Franceschi C, Campisi J . Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69 Suppl 1:S4-9. DOI: 10.1093/gerona/glu057. View

Li G, Yu M, Lee W, Tsang M, Krishnan E, Weyand C . Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med. 2012; 18(10):1518-24. PMC: 3466346. DOI: 10.1038/nm.2963. View

Philipp S, Strauss B, Hirnet D, Wissenbach U, Mery L, Flockerzi V . TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes. J Biol Chem. 2003; 278(29):26629-38. DOI: 10.1074/jbc.M304044200. View

Tan G, Yu D, Wang J, Soong T . Alternative splicing at C terminus of Ca(V)1.4 calcium channel modulates calcium-dependent inactivation, activation potential, and current density. J Biol Chem. 2011; 287(2):832-47. PMC: 3256920. DOI: 10.1074/jbc.M111.268722. View

10.

Huang M, Liao J, Bonasera S, Longo D, Goetzl E . Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 2008; 22(7):2142-50. DOI: 10.1096/fj.07-103721. View

11.

Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441(7090):235-8. DOI: 10.1038/nature04753. View

12.

Zhou X, McElhaney J . Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine. 2011; 29(11):2169-77. PMC: 3057414. DOI: 10.1016/j.vaccine.2010.12.029. View

13.

Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24(2):179-89. DOI: 10.1016/j.immuni.2006.01.001. View

14.

Matza D, Badou A, Klemic K, Stein J, Govindarajulu U, Nadler M . T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. PLoS One. 2016; 11(1):e0147379. PMC: 4729531. DOI: 10.1371/journal.pone.0147379. View

15.

Panyi G . Biophysical and pharmacological aspects of K+ channels in T lymphocytes. Eur Biophys J. 2005; 34(6):515-29. DOI: 10.1007/s00249-005-0499-3. View

16.

Linton P, Haynes L, Klinman N, Swain S . Antigen-independent changes in naive CD4 T cells with aging. J Exp Med. 1996; 184(5):1891-900. PMC: 2192899. DOI: 10.1084/jem.184.5.1891. View

17.

Jin J, Desai B, Navarro B, Donovan A, Andrews N, Clapham D . Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008; 322(5902):756-60. PMC: 2605283. DOI: 10.1126/science.1163493. View

18.

Lee G . The Balance of Th17 versus Treg Cells in Autoimmunity. Int J Mol Sci. 2018; 19(3). PMC: 5877591. DOI: 10.3390/ijms19030730. View

19.

Reynaldi A, Smith N, Schlub T, Tabilas C, Venturi V, Rudd B . Fate mapping reveals the age structure of the peripheral T cell compartment. Proc Natl Acad Sci U S A. 2019; 116(10):3974-3981. PMC: 6410819. DOI: 10.1073/pnas.1811634116. View

20.

Oh-Hora M, Rao A . Calcium signaling in lymphocytes. Curr Opin Immunol. 2008; 20(3):250-8. PMC: 2574011. DOI: 10.1016/j.coi.2008.04.004. View