Vascular Dysfunction As a Potential Culprit of Sarcopenia

Overview

Journal Exp Gerontol

Specialty Geriatrics

Date 2020 Dec 29

PMID 33373710

Citations 15

Authors

Yun Kyung Jeon

Myung Jun Shin

Sunil Kumar Saini

Carlo Custodero

Monica Aggarwal

Stephen D Anton

Christiaan Leeuwenburgh

Robert T Mankowski

Affiliations

Soon will be listed here.

Abstract

Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskeletal comorbidities, the etiology of sarcopenia, and especially the contribution of cardiovascular aging is unclear. Aging-related vascular calcification is prevalent in older adults and is a known risk factor for cardiovascular disease and death. The effect vascular calcification has on function during aging is not well understood. Emerging findings suggest vascular calcification can impact skeletal muscle perfusion, negatively affecting nutrient and oxygen delivery to skeletal muscle, ultimately accelerating muscle loss and functional decline. The present review summarizes existing evidence on the biological mechanisms linking vascular calcification with sarcopenia during aging.

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