Kikuchi's Disease with Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Dec 29

PMID 33371072

Citations 8

Authors

Wei Duan

Zheng-Hui Xiao

Long-Gui Yang

Hai-Yan Luo

Affiliations

Soon will be listed here.

Abstract

Introduction: Kikuchi's disease (KD) is a rare form of necrotizing lymphadenitis that rarely occurs in association with hemophagocytic lymphohistiocytosis (HLH) in children.

Patient Concerns: We report the case of a 4-year-5-month-old boy who suffered from fever, cervical lymphadenopathy, pancytopenia, hypertriglyceridemia, splenomegaly, low NK cell activity.

Diagnoses: A diagnosis of KD with HLH was made based on the results of biopsy of cervical lymph node and HLH-2004 trial guidelines.

Interventions: The patient was treated with corticosteroids, cyclosporine, etoposide, continuous hemodiafiltration (HDF), and plasma exchange (PE).

Outcomes: He showed a complete response to therapy, and his condition gradually improved. He was discharged on day 45 after admission due to his good recovery status.

Conclusion: HLH can be associated with KD, especially in childhood, and may have an aggressive clinical course. Continuous HDF and PE and chemotherapy should be reserved for those patients who fail to respond to IVIG and corticosteroids.

Citing Articles

A Case Report: Kikuchi Disease Associated With a Positive Auto-Immune Panel Triggered by COVID-19 Infection.

Graef A, Willett A, Dang A, Balakrishna J, Nicely C, Baiocchi R Cureus. 2024; 15(12):e50911.

PMID: 38249222 PMC: 10799691. DOI: 10.7759/cureus.50911.

Hemophagocytic lymphohistiocytosis and histiocytic necrotizing lymphadenitis secondary to hemodialysis catheter-related bloodstream infection caused by Corynebacterium Striatum.

Zhao Z, Li J, Yang L, Ren G, Zhang L, Wang T BMC Nephrol. 2023; 24(1):294.

PMID: 37803308 PMC: 10559591. DOI: 10.1186/s12882-023-03356-2.

Kikuchi-Fujimoto disease: A comprehensive review.

Mahajan V, Sharma V, Sharma N, Rani R World J Clin Cases. 2023; 11(16):3664-3679.

PMID: 37383134 PMC: 10294163. DOI: 10.12998/wjcc.v11.i16.3664.

A Rare Case of Kikuchi-Fujimoto Disease.

Qasim A, Itare V, Anwar M, Arguello Perez E Cureus. 2023; 15(5):e39098.

PMID: 37332401 PMC: 10270646. DOI: 10.7759/cureus.39098.

A young Saudi female with combined hemophagocytic lympho-histiocytosis and Kikuchi's disease: A case report.

Al-Zahrani K, Gasmelseed B, Shadi H, Al-Ansari R SAGE Open Med Case Rep. 2023; 11:2050313X231154317.

PMID: 36776208 PMC: 9909044. DOI: 10.1177/2050313X231154317.

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