Intestinal Regulatory T Cell Induction by β-elemene Alleviates the Formation of Fat Tissue-related Inflammation

Overview

Journal iScience

Publisher Cell Press

Date 2020 Dec 28

PMID 33364577

Citations 3

Authors

Yingyu Zhou

Tomohiro Takano

Yimei Wang

Xuyang Li

Rong Wang

Yoshio Wakatsuki

Haruyo Nakajima-Adachi

Masaru Tanokura

Takuya Miyakawa

Satoshi Hachimura

Affiliations

Soon will be listed here.

Abstract

The role of the intestinal immune system in the inhibition of fat tissue-related inflammation by dietary material is yet to be elucidated. Oral administration of β-elemene, contained in various foodstuffs, downregulated expressions of inflammatory cytokines and increased Foxp3CD4 T cells in adipose tissue of obese mice. However, β-elemene did not affect the inflammatory response of adipose tissue , suggesting that the inhibition observed was not due to direct interactions of adipose tissue with β-elemene. Instead, β-elemene increased Foxp3CD4 T cell population enhancing gene expressions of transforming growth factor β 1, retinaldehyde dehydrogenase 2, integrin αvβ8, and interleukin-10 in intestinal dendritic cells (DCs) and . Taken together, this study suggested the therapeutic effects of β-elemene on treating experimental obesity-induced chronic inflammation by adjusting the balance of immune cell populations in fat tissue through the generation of regulatory T cells in the intestinal immune system by modulating DC function.

Citing Articles

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