Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Overview

Journal Front Bioeng Biotechnol

Date 2020 Dec 28

PMID 33363130

Citations 9

Authors

Haozhe Yu

Wenyu Wu

Xiang Lin

Yun Feng

Affiliations

Soon will be listed here.

Abstract

Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

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