Midgut Mitochondrial Function As a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2020 Dec 28

PMID 33363053

Citations 11

Authors

Shirley Luckhart

Michael A Riehle

Affiliations

Soon will be listed here.

Abstract

Across diverse organisms, various physiologies are profoundly regulated by mitochondrial function, which is defined by mitochondrial fusion, biogenesis, oxidative phosphorylation (OXPHOS), and mitophagy. Based on our data and significant published studies from , and mammals, we propose that midgut mitochondria control midgut health and the health of other tissues in vector mosquitoes. Specifically, we argue that trade-offs among resistance to infection, metabolism, lifespan, and reproduction in vector mosquitoes are fundamentally controlled both locally and systemically by midgut mitochondrial function.

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