The Relationship Between Serum Cytokine Levels and the Degree of Psychosis and Cognitive Impairment in Patients With Methamphetamine-Associated Psychosis in Chinese Patients

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2020 Dec 28

PMID 33362607

Citations 6

Authors

Xue Yang

Hui Zhao

Xuebing Liu

Qin Xie

Xiaoliang Zhou

Qijian Deng

Gang Wang

Affiliations

Soon will be listed here.

Abstract

Cytokine levels can be changed in methamphetamine (METH) use disorders (MUDs) and primary psychosis. The present study assessed serum levels of some kinds of interleukins (ILs) in METH-associated psychosis (MAP) and their relationships with psychotic symptoms and cognitive dysfunction. Serum IL-2R, IL-6, IL-8, and IL-10 levels were examined by chemiluminescence assays in MAP patients ( = 119) and healthy controls ( = 108). The Positive and Negative Syndrome Scale (PANSS) and Montreal Cognitive Assessment (MOCA) were administered. Serum levels of IL-6 and IL-8 were significantly increased in MAP patients (all < 0.05). There was a negative relationship between IL-2R levels and PANSS positive (P) subscale scores ( = -0.193, = 0.035). IL-6, IL-8 and IL-10 levels were all negatively correlated with the naming, delayed recall and orientation subscores on the MOCA ( = -0.209, = 0.022; = -0.245, = 0.007; = -0.505, < 0.001, respectively). Our results indicate that immune disturbances are related to MAP and that IL-2R, IL-6, IL-8, and IL-10 are associated with the severity of psychotic symptoms and cognitive function impairment.

Citing Articles

Characterization of serum and brain cytokine levels following prolonged binge-like methamphetamine self-administration and cued methamphetamine seeking.

Acuna A, Nagy E, Legg J, Rodarte S, Olive M J Neuroimmunol. 2025; 400:578530.

PMID: 39854936 PMC: 11875959. DOI: 10.1016/j.jneuroim.2025.578530.

Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine.

Loftis J, Ramani S, Firsick E, Hudson R, Le-Cook A, Murnane K Front Psychiatry. 2023; 14:1259041.

PMID: 38025429 PMC: 10666795. DOI: 10.3389/fpsyt.2023.1259041.

Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels.

Kalayasiri R, Dadwat K, Thika S, Sirivichayakul S, Maes M Transl Psychiatry. 2023; 13(1):361.

PMID: 37996407 PMC: 10667231. DOI: 10.1038/s41398-023-02645-6.

The Common Denominators of Parkinson's Disease Pathogenesis and Methamphetamine Abuse.

Vincent B, Shukla M Curr Neuropharmacol. 2023; 22(13):2113-2156.

PMID: 37691228 PMC: 11337683. DOI: 10.2174/1570159X21666230907151226.

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder.

Turan C, Senormanci G, Neselioglu S, Budak Y, Erel O, Senormanci O Clin Psychopharmacol Neurosci. 2023; 21(3):572-582.

PMID: 37424424 PMC: 10335902. DOI: 10.9758/cpn.22.1047.

References

An H, Tan Y, Shi J, Wang Z, Soars J, Wu J . Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia. Schizophr Res. 2015; 162(1-3):261-8. DOI: 10.1016/j.schres.2014.12.037. View

Papageorgiou M, Raza A, Fraser S, Nurgali K, Apostolopoulos V . Methamphetamine and its immune-modulating effects. Maturitas. 2019; 121:13-21. DOI: 10.1016/j.maturitas.2018.12.003. View

Goldstein F, Zhao L, Steenland K, Levey A . Inflammation and cognitive functioning in African Americans and Caucasians. Int J Geriatr Psychiatry. 2014; 30(9):934-41. PMC: 4682666. DOI: 10.1002/gps.4238. View

Silva A, Martins T, Baptista S, Goncalves J, Agasse F, Malva J . Brain injury associated with widely abused amphetamines: neuroinflammation, neurogenesis and blood-brain barrier. Curr Drug Abuse Rev. 2011; 3(4):239-54. DOI: 10.2174/1874473711003040239. View

Kay S, Fiszbein A, Opler L . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987; 13(2):261-76. DOI: 10.1093/schbul/13.2.261. View

Karimi-Haghighi S, Dargahi L, Haghparast A . Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats. Addict Biol. 2019; 25(2):e12740. DOI: 10.1111/adb.12740. View

Sriram U, Haldar B, Cenna J, Gofman L, Potula R . Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. Front Microbiol. 2015; 6:793. PMC: 4531300. DOI: 10.3389/fmicb.2015.00793. View

Yamamoto B, Raudensky J . The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse. J Neuroimmune Pharmacol. 2008; 3(4):203-17. PMC: 3955110. DOI: 10.1007/s11481-008-9121-7. View

Persidsky Y, Ramirez S, Haorah J, Kanmogne G . Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol. 2007; 1(3):223-36. DOI: 10.1007/s11481-006-9025-3. View

10.

Lapchak P . A role for interleukin-2 in the regulation of striatal dopaminergic function. Neuroreport. 1992; 3(2):165-8. DOI: 10.1097/00001756-199202000-00011. View

11.

Zalcman S, Green-Johnson J, Murray L, Nance D, Dyck D, Anisman H . Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res. 1994; 643(1-2):40-9. DOI: 10.1016/0006-8993(94)90006-x. View

12.

Wu X, Li X, Li Y, Kong L, Fang J, Zhou X . The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen. Drug Alcohol Depend. 2015; 159:66-71. DOI: 10.1016/j.drugalcdep.2015.11.021. View

13.

Freire-Garabal M, Balboa J, Nunez M, Castano M, Llovo J, Belmonte A . Effects of amphetamine on T-cell immune response in mice. Life Sci. 1991; 49(16):PL107-12. DOI: 10.1016/0024-3205(91)90570-2. View

14.

Banks W, Kastin A, Broadwell R . Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation. 1995; 2(4):241-8. DOI: 10.1159/000097202. View

15.

Bowyer J, Ali S . High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synapse. 2006; 60(7):521-32. DOI: 10.1002/syn.20324. View

16.

Shah A, Silverstein P, Singh D, Kumar A . Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. J Neuroinflammation. 2012; 9:52. PMC: 3338363. DOI: 10.1186/1742-2094-9-52. View

17.

Potula R, Hawkins B, Cenna J, Fan S, Dykstra H, Ramirez S . Methamphetamine causes mitrochondrial oxidative damage in human T lymphocytes leading to functional impairment. J Immunol. 2010; 185(5):2867-76. PMC: 3124898. DOI: 10.4049/jimmunol.0903691. View

18.

Rawson R, Condon T . Why do we need an Addiction supplement focused on methamphetamine?. Addiction. 2007; 102 Suppl 1:1-4. DOI: 10.1111/j.1360-0443.2006.01781.x. View

19.

McCANN S, Kimura M, Karanth S, Yu W, Mastronardi C, Rettori V . The mechanism of action of cytokines to control the release of hypothalamic and pituitary hormones in infection. Ann N Y Acad Sci. 2001; 917:4-18. DOI: 10.1111/j.1749-6632.2000.tb05368.x. View

20.

DU S, Zhang W, Yue X, Luo X, Tan X, Liu C . Role of CXCR1 and Interleukin-8 in Methamphetamine-Induced Neuronal Apoptosis. Front Cell Neurosci. 2018; 12:230. PMC: 6085841. DOI: 10.3389/fncel.2018.00230. View