Atypical Enteropathogenic Escherichia Coli: from Kittens to Humans and Beyond!

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2020 Dec 28

PMID 33361199

Citations 1

Authors

Shantanu Bhatt

Affiliations

Soon will be listed here.

Abstract

Atypical enteropathogenic (aEPEC) are associated with diarrhea worldwide, yet genome-wide investigations to probe their virulome are lacking. In this issue of , V. E. Watson, T. H. Hazen, D. A. Rasko, M. E. Jacob, et al. (IAI 89:e00619-20, 2020, https://doi.org/10.1128/IAI.00619-20) sequenced aEPEC isolates from diarrheic and asymptomatic kittens. Using phylogenomics, they demonstrated that these isolates were genetically indistinguishable from human isolates, suggesting that kittens may serve as a reservoir and, perhaps, a much-needed model to interrogate aEPEC virulence. The diarrheic isolates were hypermotile, suggesting that this phenotype may distinguish virulent strains from their innocuous counterparts.

Citing Articles

Identification of a genomic cluster related to hypersecretion of intestinal mucus and mucinolytic activity of atypical enteropathogenic (aEPEC).

Trovao L, Vieira M, Santos A, Puno-Sarmiento J, Nunes P, Santos F Front Cell Infect Microbiol. 2024; 14:1393369.

PMID: 39703371 PMC: 11656320. DOI: 10.3389/fcimb.2024.1393369.

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