Generation of an IPSC Line (AKOSi004-A) from Fibroblasts of a Female Adult NPC1 Patient, Carrying the Compound Heterozygous Mutation P.Val1023Serfs*15/p.Gly992Arg and of an IPSC Line (AKOSi005-A) from a Female Adult Control Individual

Niemann-Pick disease Type C (NPC) is a rare progressive neurodegenerative disorder with an incidence of 1:120,000 caused by mutations in the NPC1 or NPC2 gene leading to a massive cholesterol accumulation. Here, we describe the generation of induced pluripotent stem cells (iPSCs) of an affected female adult individual carrying the NPC1 mutation p.Val1023Serfs*15/p.Gly992Arg and an iPSC line from an unrelated healthy female adult control individual. Human iPSCs were derived from fibroblasts using retroviruses carrying the four reprogramming factors OCT4, SOX2, KLF4 and C-MYC. These lines provide a valuable resource for studying the pathophysiology of NPC and for pharmacological intervention.