Early Antibiotic Use is Associated with CMV Risk and Outcomes Following Allogeneic Hematopoietic Cell Transplantation

Overview

Journal Blood Adv

Specialty Hematology

Date 2020 Dec 22

PMID 33351132

Citations 3

Authors

Jose F Camargo

Anthony D Anderson

Yoichiro Natori

Akina Natori

Michele I Morris

Denise Pereira

Krishna V Komanduri

Affiliations

Soon will be listed here.

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Clinical presentation and outcomes of COVID-19 following hematopoietic cell transplantation and cellular therapy.

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References

Teira P, Battiwalla M, Ramanathan M, Barrett A, Ahn K, Chen M . Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis. Blood. 2016; 127(20):2427-38. PMC: 4874224. DOI: 10.1182/blood-2015-11-679639. View

Mullane K, Winston D, Nooka A, Morris M, Stiff P, Dugan M . A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile-associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation. Clin Infect Dis. 2018; 68(2):196-203. PMC: 6321849. DOI: 10.1093/cid/ciy484. View

Taur Y, Jenq R, Perales M, Littmann E, Morjaria S, Ling L . The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood. 2014; 124(7):1174-82. PMC: 4133489. DOI: 10.1182/blood-2014-02-554725. View

Camargo J, Kimble E, Rosa R, Shimose L, Bueno M, Jeyakumar N . Impact of Cytomegalovirus Viral Load on Probability of Spontaneous Clearance and Response to Preemptive Therapy in Allogeneic Stem Cell Transplantation Recipients. Biol Blood Marrow Transplant. 2017; 24(4):806-814. DOI: 10.1016/j.bbmt.2017.11.038. View

Weber D, Jenq R, Peled J, Taur Y, Hiergeist A, Koestler J . Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017; 23(5):845-852. PMC: 5546237. DOI: 10.1016/j.bbmt.2017.02.006. View

Marty F, Ljungman P, Chemaly R, Maertens J, Dadwal S, Duarte R . Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation. N Engl J Med. 2017; 377(25):2433-2444. DOI: 10.1056/NEJMoa1706640. View

Green M, Leisenring W, Xie H, Mast T, Cui Y, Sandmaier B . Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol. 2016; 3(3):e119-27. PMC: 4914379. DOI: 10.1016/S2352-3026(15)00289-6. View

Murthy H, Gharaibeh R, Al-Mansour Z, Kozlov A, Trikha G, Newsome R . Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2020; 26(11):2001-2010. DOI: 10.1016/j.bbmt.2020.07.023. View

Haak B, Littmann E, Chaubard J, Pickard A, Fontana E, Adhi F . Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood. 2018; 131(26):2978-2986. PMC: 6024637. DOI: 10.1182/blood-2018-01-828996. View

10.

Camargo J, Wieder E, Kimble E, Benjamin C, Kolonias D, Kwon D . Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation. Blood. 2018; 133(8):867-877. DOI: 10.1182/blood-2018-10-878918. View

11.

Ljungman P, Boeckh M, Hirsch H, Josephson F, Lundgren J, Nichols G . Definitions of Cytomegalovirus Infection and Disease in Transplant Patients for Use in Clinical Trials. Clin Infect Dis. 2016; 64(1):87-91. DOI: 10.1093/cid/ciw668. View

12.

Taur Y, Xavier J, Lipuma L, Ubeda C, Goldberg J, Gobourne A . Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012; 55(7):905-14. PMC: 3657523. DOI: 10.1093/cid/cis580. View

13.

Shono Y, van den Brink M . Empiric antibiotic use in allogeneic hematopoietic cell transplantation: should we avoid anaerobe coverage?. Blood Adv. 2018; 1(25):2325-2328. PMC: 5729613. DOI: 10.1182/bloodadvances.2017005108. View

14.

Zhang S, Shanley R, Weisdorf D, Rashidi A . Vancomycin use and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. Blood Adv. 2020; 4(12):2640-2643. PMC: 7322945. DOI: 10.1182/bloodadvances.2020001984. View

15.

Peled J, Gomes A, Devlin S, Littmann E, Taur Y, Sung A . Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020; 382(9):822-834. PMC: 7534690. DOI: 10.1056/NEJMoa1900623. View

16.

Shono Y, Docampo M, Peled J, Perobelli S, Velardi E, Tsai J . Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016; 8(339):339ra71. PMC: 4991773. DOI: 10.1126/scitranslmed.aaf2311. View

17.

Jenq R, Ubeda C, Taur Y, Menezes C, Khanin R, Dudakov J . Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med. 2012; 209(5):903-11. PMC: 3348096. DOI: 10.1084/jem.20112408. View