Multifunctional Amyloids in the Biology of Gram-Positive Bacteria

Overview

Journal Microorganisms

Specialty Microbiology

Date 2020 Dec 22

PMID 33348645

Citations 8

Authors

Ana Alvarez-Mena

Jesus Camara-Almiron

Antonio de Vicente

Diego Romero

Affiliations

Soon will be listed here.

Abstract

Since they were discovered, amyloids have proven to be versatile proteins able to participate in a variety of cellular functions across all kingdoms of life. This multitask trait seems to reside in their ability to coexist as monomers, aggregates or fibrillar entities, with morphological and biochemical peculiarities. It is precisely this common molecular behaviour that allows amyloids to cross react with one another, triggering heterologous aggregation. In bacteria, many of these functional amyloids are devoted to the assembly of biofilms by organizing the matrix scaffold that keeps cells together. However, consistent with their notion of multifunctional proteins, functional amyloids participate in other biological roles within the same organisms, and emerging unprecedented functions are being discovered. In this review, we focus on functional amyloids reported in gram-positive bacteria, which are diverse in their assembly mechanisms and remarkably specific in their biological functions that they perform. Finally, we consider cross-seeding between functional amyloids as an emerging theme in interspecies interactions that contributes to the diversification of bacterial biology.

Citing Articles

Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids.

Sanchez J, Lopez-Laguna H, Parlade E, Di Somma A, Livieri A, Alamo P Adv Sci (Weinh). 2024; 11(21):e2309427.

PMID: 38501900 PMC: 11151067. DOI: 10.1002/advs.202309427.

Staphylococcal superantigen-like protein 10 enhances the amyloidogenic biofilm formation in Staphylococcus aureus.

Rahman S, Das A BMC Microbiol. 2023; 23(1):390.

PMID: 38062361 PMC: 10701973. DOI: 10.1186/s12866-023-03134-y.

Molecular characterization of the N-terminal half of TasA during amyloid-like assembly and its contribution to Bacillus subtilis biofilm formation.

Camara-Almiron J, Dominguez-Garcia L, El Mammeri N, Lends A, Habenstein B, de Vicente A NPJ Biofilms Microbiomes. 2023; 9(1):68.

PMID: 37739955 PMC: 10516879. DOI: 10.1038/s41522-023-00437-w.

Beyond One-Trick Ponies: The Multifunctional Marvels of Microbial Functional Amyloids.

Landau M Microorganisms. 2023; 11(5).

PMID: 37317177 PMC: 10221729. DOI: 10.3390/microorganisms11051201.

Amyloids and prions in the light of evolution.

Galkin A, Sysoev E, Valina A Curr Genet. 2023; 69(4-6):189-202.

PMID: 37165144 DOI: 10.1007/s00294-023-01270-6.

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