Reply to "Comment on López-Yerena Et Al. 'Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats' 2020, , 134"

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2020 Dec 22

PMID 33348608

Citations 5

Authors

Anallely Lopez-Yerena

Anna Vallverdu-Queralt

Raf Mols

Patrick Augustijns

Rosa M Lamuela-Raventos

Elvira Escribano-Ferrer

Affiliations

Soon will be listed here.

Abstract

Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Later, comments on our published paper were released, requesting clarification of specific data. In this detailed reply, we hope to have addressed and clarified all the concerns of A. Kaddoumi and K. El Sayed and that the scientific community will benefit from both the study and the comments it has generated.

Citing Articles

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Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique.

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Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats.

Lopez-Yerena A, Vallverdu-Queralt A, Jauregui O, Garcia-Sala X, Lamuela-Raventos R, Escribano-Ferrer E Antioxidants (Basel). 2021; 10(5).

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