A Polymorphism in the 3'-untranslated Region of the Matrix Metallopeptidase 9 Gene is Associated with Susceptibility to Idiopathic Calcium Nephrolithiasis in the Chinese Population

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2020 Dec 21

PMID 33345667

Citations 4

Authors

Qiang Bu

Yu Zhu

Qiao-Yun Chen

Hao Li

Yan Pan

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate whether single nucleotide polymorphisms (SNPs) in the 3' untranslated region (UTR) of the matrix metallopeptidase 9 gene () are associated with susceptibility to calcium oxalate stones.

Methods: A total of 428 patients with kidney stone disease (KSD) and 450 control individuals were enrolled. Three SNPs (rs20544, rs9509, and rs1056628) were genotyped, and mRNA and protein expression was determined in patients and controls. The dual luciferase reporter gene assay was conducted by transfecting HEK293 cells with miR-491-5p mimics and plasmids containing with rs1056628 AA/CC genotypes.

Results: The rs1056628 CC genotype was significantly increased in KSD patients compared with controls (CC vs AA: odds ratio [OR] = 2.279, 95% confidence interval [CI] = 1.048-4.956). The rs1056628 C allele frequency was higher in KSD patients than controls. The increased KSD risks associated with rs1056628 were more evident in individuals aged <30 years (OR = 3.504, 95% CI = 1.102-11.139) and men (OR = 2.522, 95% CI = 1.004-6.334). mRNA and protein levels of were significantly higher in KSD patients with the CC genotype than in those with the AA genotype.

Conclusion: This study demonstrates that SNP rs1056628 is associated with a significant KSD risk in Chinese Han individuals.

Citing Articles

A functional -1562C>T polymorphism, MMP-9 serum levels and nephrolithiasis risk in a southern Chinese population.

Ding Q, Cao C, Shi Y, Fan Z, Li F, Tu W Front Med (Lausanne). 2023; 10:1175798.

PMID: 37332754 PMC: 10272514. DOI: 10.3389/fmed.2023.1175798.

Effects of SNPs and SNP-Environment Interactions on Serum Lipid Profiles and the Risk of Early-Onset Coronary Artery Disease in the Chinese Population.

Zheng P, Chen L, Pan H, Liu P, Zheng Z Front Cardiovasc Med. 2022; 9:882728.

PMID: 35783856 PMC: 9240353. DOI: 10.3389/fcvm.2022.882728.

Ox-LDL Aggravates the Oxidative Stress and Inflammatory Responses of THP-1 Macrophages by Reducing the Inhibition Effect of miR-491-5p on MMP-9.

Liao Y, Zhu E, Zhou W Front Cardiovasc Med. 2021; 8:697236.

PMID: 34660709 PMC: 8517139. DOI: 10.3389/fcvm.2021.697236.

The Molecular Aspect of Nephrolithiasis Development.

Wigner P, Grebowski R, Bijak M, Szemraj J, Saluk-Bijak J Cells. 2021; 10(8).

PMID: 34440695 PMC: 8393760. DOI: 10.3390/cells10081926.

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