Obesity, Dyslipidemia, and High Blood Pressure Are Associated with Cardiovascular Risk, Determined Using High-sensitivity C-reactive Protein Concentration, in Young Adults

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2020 Dec 21

PMID 33342336

Citations 6

Authors

Luz Elena Ramos-Arellano

Ines Matia-Garcia

Linda Anahi Marino-Ortega

Natividad Castro-Alarcon

Jose Francisco Munoz-Valle

Lorenzo Salgado-Goytia

Aralia Berenice Salgado-Bernabe

Isela Parra-Rojas

Affiliations

Soon will be listed here.

Abstract

Objective: Few studies have investigated the relationships between high-sensitivity C-reactive protein (hs-CRP) concentration and conventional cardiometabolic markers in young adults. The aim of this study was to characterize the cardiometabolic profile of young adults who are at high cardiovascular risk, according to hs-CRP concentration.

Methods: A cross-sectional study was conducted in 300 young adults (18 to 30 years old) from southern Mexico (n = 150 normal-weight and n = 150 obese). Their circulating lipid and glucose concentrations were measured using colorimetric enzymatic assays, and their hs-CRP, ApoA, and ApoB concentrations were measured using turbidimetric assays.

Results: The most prevalent abnormalities in the participants with high cardiovascular risk, determined using an hs-CRP >28.57 nmol/L, were high waist circumference (85.7%), obesity (83.9%), high low-density lipoprotein-cholesterol (64.3%), low high-density lipoprotein-cholesterol (50%), Apo B in the highest tertile (39.3%), hypertriglyceridemia (35.7%), and high blood pressure (30.4%). In addition, there were strong associations between hs-CRP >28.57 nmol/L and obesity (odds ratio [OR] = 13.9), high waist circumference (OR = 8.0), hypertriglyceridemia (OR = 4.0), high blood pressure (OR = 3.4), hypercholesterolemia (OR = 2.8), and Apo B in the highest tertile (OR = 2.4).

Conclusion: The principal cardiometabolic alterations associated with high cardiovascular risk, determined using hs-CRP, are obesity, dyslipidemia, and high blood pressure in young adults.

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