Lifetime Allergy Symptoms in IgG4-Related Disease: A Case-Control Study

Overview

Journal Arthritis Care Res (Hoboken)

Specialty Rheumatology

Date 2020 Dec 20

PMID 33342079

Citations 11

Authors

Samantha Sanders

Xiaoqing Fu

Yuqing Zhang

Cory A Perugino

Rachel Wallwork

Emanuel Della-Torre

Liam Harvey

Tyler Harkness

Aidan Long

Hyon K Choi

John H Stone

Zachary S Wallace

Affiliations

Soon will be listed here.

Abstract

Objective: The etiology of IgG4-related disease (IgG4-RD) is unknown, and there has been controversy over the significance of allergic conditions in IgG4-RD. We examined the prevalence of lifetime allergy symptoms in IgG4-RD and the association between these and IgG4-RD.

Methods: We identified IgG4-RD patients and non-IgG4-RD controls without autoimmune conditions seen at a single center. IgG4-RD patients were classified using the American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria. Allergy symptoms were ascertained by questionnaire. We assessed the association of IgG4-RD features with allergy symptoms. We compared the proportion of cases and controls with allergy symptoms using conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) after matching cases and controls 1:1 by age and sex.

Results: Lifetime allergy symptoms were reported by 165 (71%) of 231 IgG4-RD patients. Aeroallergen symptoms were most commonly reported (n = 135, 58%), followed by skin allergy symptoms (n = 97, 42%) and food allergy symptoms (n = 47, 20%). IgG4-RD cases with a history of allergy symptoms were more likely to have head and neck involvement (OR 2.0 [95% CI 1.1-3.6]) and peripheral eosinophilia (OR 3.3 [95% CI 1.2-9.0]) than those without allergy symptoms. The prevalence of any allergy symptoms was similar between cases and controls (OR 0.7 [95% CI 0.4-1.1]); this remained consistent after stratifying by head and neck involvement.

Conclusion: Lifetime allergy symptoms are common in IgG4-RD but are not reported more often in IgG4-RD compared to non-IgG4-RD patients without autoimmune conditions. These findings suggest that allergies are not uniquely associated with the pathogenesis or presentation of IgG4-RD.

Citing Articles

Current and future advances in practice: IgG4-related disease.

Wallace Z, Katz G, Hernandez-Barco Y, Baker M Rheumatol Adv Pract. 2024; 8(2):rkae020.

PMID: 38601138 PMC: 11003820. DOI: 10.1093/rap/rkae020.

IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease.

Motta R, Culver E Front Immunol. 2024; 15:1272084.

PMID: 38433835 PMC: 10904653. DOI: 10.3389/fimmu.2024.1272084.

Zuo A, Liu X, Guo Z, Jiang Y, Lu D Front Med (Lausanne). 2023; 10:1247884.

PMID: 38089862 PMC: 10715397. DOI: 10.3389/fmed.2023.1247884.

Assessment of patient-reported symptoms and distress in IgG4-related disease (IgG4-RD): Development, clinical validation, and content validation of the IgG4-RD Symptom Severity Index.

Wallace Z, McMahon G, Hang B, Fu X, Harkness T, Donelan K Semin Arthritis Rheum. 2023; 63:152253.

PMID: 37619485 PMC: 11004491. DOI: 10.1016/j.semarthrit.2023.152253.

Implication of allergy and atopy in IgG4-related disease.

DAstous-Gauthier K, Ebbo M, Chanez P, Schleinitz N World Allergy Organ J. 2023; 16(4):100765.

PMID: 37179536 PMC: 10172607. DOI: 10.1016/j.waojou.2023.100765.

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