Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis

Background: Postoperative atrial fibrillation (POAF) is common after cardiac surgery and linked to poorer short-term and long-term outcomes; however, conflicting evidence exists on stroke risk and how the index procedure affects outcomes. This study aims to provide a comprehensive review of the published outcomes of POAF after cardiac surgery, examined as a whole and by index procedure.

Methods: A systematic review of POAF after cardiac surgery was conducted. Outcomes related to POAF were analyzed in a meta-analysis, and aggregate survival data were derived to examine long-term survival.

Results: Sixty-one studies with 239,018 patients were identified, the majority (78.7%) undergoing coronary surgery. POAF occurred in 25.5% of patients and was associated with significantly higher rates of early mortality and stroke (odds ratio [OR], 1.74; P < .001; and OR, 2.21, P < .001, respectively) along with longer intensive care and overall hospital length of stay (mean difference 0.8 days, P = .008; and mean difference 2.8 days, P < .001, respectively). After a median of 6.6 years (range, 0.5-20 years), mortality and stroke remained significantly higher for those with POAF (OR, 1.57, P < .001; and OR, 1.81, P = .001). Pooled hazard ratio for long-term mortality was significantly higher for patients who underwent coronary surgery compared with isolated valve surgery.

Conclusions: POAF is common after cardiac surgery and is associated with significantly higher rates of both short-term and long-term stroke and mortality as well as increased hospital stay. Differences in hazard for long-term survival may be due to the underlying pathophysiological risk factors for POAF, which differ by surgical procedure.